BZP23_ARATH
ID BZP23_ARATH Reviewed; 249 AA.
AC Q8GTS2; Q9SLE1;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Basic leucine zipper 23 {ECO:0000303|PubMed:11906833};
DE Short=AtbZIP23 {ECO:0000303|PubMed:11906833};
DE Short=bZIP protein 23 {ECO:0000305};
GN Name=BZIP23 {ECO:0000303|PubMed:11906833};
GN OrderedLocusNames=At2g16770 {ECO:0000312|Araport:AT2G16770};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11906833; DOI=10.1016/s1360-1385(01)02223-3;
RA Jakoby M., Weisshaar B., Droege-Laser W., Vicente-Carbajosa J.,
RA Tiedemann J., Kroj T., Parcy F.;
RT "bZIP transcription factors in Arabidopsis.";
RL Trends Plant Sci. 7:106-111(2002).
RN [6]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20479230; DOI=10.1073/pnas.1004788107;
RA Assuncao A.G., Herrero E., Lin Y.F., Huettel B., Talukdar S., Smaczniak C.,
RA Immink R.G., van Eldik M., Fiers M., Schat H., Aarts M.G.;
RT "Arabidopsis thaliana transcription factors bZIP19 and bZIP23 regulate the
RT adaptation to zinc deficiency.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:10296-10301(2010).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=26306426; DOI=10.1111/tpj.12996;
RA Inaba S., Kurata R., Kobayashi M., Yamagishi Y., Mori I., Ogata Y.,
RA Fukao Y.;
RT "Identification of putative target genes of bZIP19, a transcription factor
RT essential for Arabidopsis adaptation to Zn deficiency in roots.";
RL Plant J. 84:323-334(2015).
CC -!- FUNCTION: Transcription factor involved in the response to zinc ion
CC deficiency. Binds to the consensus sequence 5'-[AG]TGTCGACA[CT]-3' also
CC called zinc deficiency response element (ZDRE). The ZDRE sequence is
CC conserved in the plant kingdom and present in the promoters of genes
CC that constitute the primary response to zinc deficiency, comprising
CC additional ZIP metal transporter genes (PubMed:20479230,
CC PubMed:26306426). Required for zinc accumulation in roots. Mediates the
CC expression of the zinc transporter ZIP12 during growth in zinc-
CC deficient conditions. ZIP12 transporter is involved in zinc uptake in
CC roots (PubMed:26306426). {ECO:0000269|PubMed:20479230,
CC ECO:0000269|PubMed:26306426}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978,
CC ECO:0000269|PubMed:26306426}.
CC -!- INDUCTION: Induced by zinc deficiency. {ECO:0000269|PubMed:20479230}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions (PubMed:20479230, PubMed:26306426). Mutant seedlings grown
CC under normal conditions accumulate reduced levels of zinc in roots.
CC Mutant seedlings grown in zinc-depleted medium have reduced root length
CC (PubMed:26306426). {ECO:0000269|PubMed:20479230,
CC ECO:0000269|PubMed:26306426}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD24610.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005825; AAD24610.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06536.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61918.1; -; Genomic_DNA.
DR EMBL; AK117479; BAC42143.1; -; mRNA.
DR EMBL; BT029022; ABI93931.1; -; mRNA.
DR PIR; A84544; A84544.
DR RefSeq; NP_001324107.1; NM_001335489.1.
DR RefSeq; NP_179268.2; NM_127229.3.
DR AlphaFoldDB; Q8GTS2; -.
DR SMR; Q8GTS2; -.
DR IntAct; Q8GTS2; 1.
DR STRING; 3702.AT2G16770.1; -.
DR PaxDb; Q8GTS2; -.
DR PRIDE; Q8GTS2; -.
DR ProteomicsDB; 240514; -.
DR EnsemblPlants; AT2G16770.1; AT2G16770.1; AT2G16770.
DR EnsemblPlants; AT2G16770.2; AT2G16770.2; AT2G16770.
DR GeneID; 816178; -.
DR Gramene; AT2G16770.1; AT2G16770.1; AT2G16770.
DR Gramene; AT2G16770.2; AT2G16770.2; AT2G16770.
DR KEGG; ath:AT2G16770; -.
DR Araport; AT2G16770; -.
DR TAIR; locus:2059851; AT2G16770.
DR eggNOG; ENOG502QVJ4; Eukaryota.
DR HOGENOM; CLU_065260_1_0_1; -.
DR InParanoid; Q8GTS2; -.
DR OMA; PSAYVMN; -.
DR OrthoDB; 1088448at2759; -.
DR PhylomeDB; Q8GTS2; -.
DR PRO; PR:Q8GTS2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8GTS2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010043; P:response to zinc ion; IEP:TAIR.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF07716; bZIP_2; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..249
FT /note="Basic leucine zipper 23"
FT /id="PRO_0000435721"
FT DOMAIN 74..121
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 66..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..98
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 102..116
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ SEQUENCE 249 AA; 27300 MW; C43ECAC57772251B CRC64;
MDDGELEFSN SNMGGELPSC SMDSFFDELL RDSHACTHTH TCNPPGPENT HTHTCLHVHT
KILPDKVSTD DTSESSGKKR PLGNREAVRK YREKKKAKAA SLEDEVMRLK AVNNQLLKRL
QGQAALEAEV TRLKCLLVDI RGRIDGEIGA FPYQKPAVTN VPYSYMMHPC NMQCDVDNLY
CLQNGNNGEG ASMNEQGLNG CEFDQLECLA NQNLAGKEIP VCSNGIGTFT VNGSGVNKRK
GEPRAAKAV
