BZPE_DICDI
ID BZPE_DICDI Reviewed; 418 AA.
AC Q55E93;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Probable basic-leucine zipper transcription factor E;
GN Name=bzpE; ORFNames=DDB_G0269338;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=16410410; DOI=10.1242/dev.02240;
RA Huang E., Blagg S.L., Keller T., Katoh M., Shaulsky G., Thompson C.R.L.;
RT "bZIP transcription factor interactions regulate DIF responses in
RT Dictyostelium.";
RL Development 133:449-458(2006).
CC -!- FUNCTION: Probable transcriptional regulator. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72019.1; -; Genomic_DNA.
DR RefSeq; XP_645888.1; XM_640796.1.
DR AlphaFoldDB; Q55E93; -.
DR SMR; Q55E93; -.
DR STRING; 44689.DDB0220089; -.
DR PaxDb; Q55E93; -.
DR EnsemblProtists; EAL72019; EAL72019; DDB_G0269338.
DR GeneID; 8616830; -.
DR KEGG; ddi:DDB_G0269338; -.
DR dictyBase; DDB_G0269338; bzpE.
DR eggNOG; ENOG502RC8F; Eukaryota.
DR HOGENOM; CLU_657918_0_0_1; -.
DR InParanoid; Q55E93; -.
DR Reactome; R-DDI-5632684; Hedgehog 'on' state.
DR PRO; PR:Q55E93; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0030162; P:regulation of proteolysis; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
PE 3: Inferred from homology;
KW Coiled coil; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..418
FT /note="Probable basic-leucine zipper transcription factor
FT E"
FT /id="PRO_0000384405"
FT DOMAIN 246..309
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 51..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..268
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 274..281
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 336..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..47
FT /evidence="ECO:0000255"
FT COILED 324..362
FT /evidence="ECO:0000255"
FT COMPBIAS 95..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..237
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 47386 MW; 97C0A4C6C8502FDB CRC64;
MDDQQLTIQQ IQQLHMLLQQ QQQQQQQQQQ QQQQQQQQLQ QQNFQLTPQN FQIPVNNNNN
NNNNSNNNNN NETAFNITSQ NNSIAANLNN DTNIINTTTT TTNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNTAPNQKF PTRKYKKQKD KLAELGIDVE LSKKPTAAVK KKPPAKKSAK
NAASQPTSPT LSTTNTSSAF TTAVLDTKKR KNQELLDYSD NSEESDSDEE DFENGDNENG
DFPGGGDRKN RRLLKNREAA QLFRQRQKEY INSLESKASS LEASNTTALS KVSHLTEENQ
LMKDKVRYLK NFVKQAVSIS LPMSVVNQDN INNLNNNLNG LQNQQNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNQNNFNN NNNNNINNNI TFNNNNNNNS NNNNSNNIDS LLFNLPPD
