BZPL_DICDI
ID BZPL_DICDI Reviewed; 530 AA.
AC Q54Q90;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Probable basic-leucine zipper transcription factor L;
GN Name=bzpL; ORFNames=DDB_G0284023;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=16410410; DOI=10.1242/dev.02240;
RA Huang E., Blagg S.L., Keller T., Katoh M., Shaulsky G., Thompson C.R.L.;
RT "bZIP transcription factor interactions regulate DIF responses in
RT Dictyostelium.";
RL Development 133:449-458(2006).
CC -!- FUNCTION: Probable transcriptional regulator. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; AAFI02000059; EAL65435.1; -; Genomic_DNA.
DR RefSeq; XP_638790.1; XM_633698.1.
DR AlphaFoldDB; Q54Q90; -.
DR SMR; Q54Q90; -.
DR STRING; 44689.DDB0216259; -.
DR PaxDb; Q54Q90; -.
DR EnsemblProtists; EAL65435; EAL65435; DDB_G0284023.
DR GeneID; 8624379; -.
DR KEGG; ddi:DDB_G0284023; -.
DR dictyBase; DDB_G0284023; bzpL.
DR eggNOG; ENOG502RHD8; Eukaryota.
DR HOGENOM; CLU_514309_0_0_1; -.
DR InParanoid; Q54Q90; -.
DR OMA; GMESPTI; -.
DR Reactome; R-DDI-381033; ATF6 (ATF6-alpha) activates chaperones.
DR PRO; PR:Q54Q90; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..530
FT /note="Probable basic-leucine zipper transcription factor
FT L"
FT /id="PRO_0000384410"
FT DOMAIN 55..118
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..77
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 83..104
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 142..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 58397 MW; 127BDE2FC4047672 CRC64;
MYSPSSPQSS EPMSPESDYG GGNSINNSNS SNNSSANQSP QFSVGKMKVD SEEKVKKRQV
RLLKNRQSAA LSRSRKKEYI ANLESKAQEL THSTQELHVQ YNKISSTTFE TKSRLEFLEK
SLRSLRMENE FLRTKFEDIN NNNIKSHSRS NSSSSSLSSS PTTPNTTTTT TTSTTPVQLI
INNHKSESSP LLLNSTNSSP TIASTLINTK DIINVSQNKN NNNNNNNNNN NNNNNNNNNN
NNNNTTNLLD QQQQSPTPVL ESLIKKDRER EILIGINKIN HFKFNNNNIN NINNINNNNN
NINNIVNDEE DEEKCKINSV EESNSNHLNN NFSNLSFSSP NVNSQPIYLT RVRSSSYHPS
NYLGMESPTI NAGHHMIIPT ESLILSSNHH HHHHNNINNN SNNHYHHESS TASSSSGGNK
LPSLYSITNN LGGGNSSSPS SSSTSSPSTS SPSTPKSMGF PSPIFIGSSG SGPSSSGSQI
NHRSSIIGLS KLKSYNNNNN SNNNNSPILY PISTNQYPSL INNNNNNNNY
