ID   TRPB_CAUVC              Reviewed;         406 AA.
AC   P12290;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 148.
DE   RecName: Full=Tryptophan synthase beta chain;
DE            EC=4.2.1.20;
GN   Name=trpB; OrderedLocusNames=CC_3544;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2828322; DOI=10.1128/jb.170.2.757-768.1988;
RA   Ross C.M., Winkler M.E.;
RT   "Structure of the Caulobacter crescentus trpFBA operon.";
RL   J. Bacteriol. 170:757-768(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: The beta subunit is responsible for the synthesis of L-
CC       tryptophan from indole and L-serine. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-
CC         glyceraldehyde 3-phosphate + H2O + L-tryptophan;
CC         Xref=Rhea:RHEA:10532, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384,
CC         ChEBI:CHEBI:57912, ChEBI:CHEBI:58866, ChEBI:CHEBI:59776; EC=4.2.1.20;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 5/5.
CC   -!- SUBUNIT: Tetramer of two alpha and two beta chains. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TrpB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK25506.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M19129; AAA23057.1; -; Genomic_DNA.
DR   EMBL; AE005673; AAK25506.1; ALT_INIT; Genomic_DNA.
DR   PIR; C43664; C43664.
DR   PIR; F87688; F87688.
DR   RefSeq; NP_422338.1; NC_002696.2.
DR   RefSeq; WP_024265976.1; NC_002696.2.
DR   AlphaFoldDB; P12290; -.
DR   SMR; P12290; -.
DR   STRING; 190650.CC_3544; -.
DR   EnsemblBacteria; AAK25506; AAK25506; CC_3544.
DR   KEGG; ccr:CC_3544; -.
DR   PATRIC; fig|190650.5.peg.3549; -.
DR   eggNOG; COG0133; Bacteria.
DR   HOGENOM; CLU_016734_3_1_5; -.
DR   OMA; HGMKSYF; -.
DR   UniPathway; UPA00035; UER00044.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0004834; F:tryptophan synthase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd06446; Trp-synth_B; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   HAMAP; MF_00133; Trp_synth_beta; 1.
DR   InterPro; IPR001926; PLP-dep.
DR   InterPro; IPR006653; Trp_synth_b_CS.
DR   InterPro; IPR006654; Trp_synth_beta.
DR   InterPro; IPR023026; Trp_synth_beta/beta-like.
DR   InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR   Pfam; PF00291; PALP; 1.
DR   PIRSF; PIRSF001413; Trp_syn_beta; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
DR   TIGRFAMs; TIGR00263; trpB; 1.
DR   PROSITE; PS00168; TRP_SYNTHASE_BETA; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase;
KW   Pyridoxal phosphate; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..406
FT                   /note="Tryptophan synthase beta chain"
FT                   /id="PRO_0000098937"
FT   MOD_RES         99
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   406 AA;  43491 MW;  83A8161FF477511E CRC64;
     MNAPAKPNDY SAYPDAEGRF GGFGGRYVAE TLMPLVLDLG KAYADAKADP EFQAQLKSYN
     THYAGRPSPL YFAERLTEHF GGAKIYFKRD ELNHTGSHKI NNALGQILLA MRMGKTRIIA
     ETGAGQHGVA TATVCARFGL PCVVYMGATD VERQKPNVFR MNLLGAEVRP VSSGTGTLKD
     AMNEAMRDWV TNVHDTYYLI GTAAGPHPYP VMVRDFQSVI GAEAREQILE MEGRLPDAVV
     ACIGGGSNAI GLFHPFLGDE GVRLIGVEAA GHGVSTDKHA ASLTGGRPGV LHGNRTYLLQ
     DDDGQIIDAH SISAGLDYPG IGPEHSFLHD IGRAEYVSTT DTEALEAFKL CSTLEGIIPA
     LEPAHALARV GEIAQELGKG KIVVMNLCGR GDKDIFTVAE ALGRKI