ID   C04C1_PINTA             Reviewed;         518 AA.
AC   Q50EK3;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Cytochrome P450 704C1;
DE            EC=1.14.-.-;
DE   AltName: Full=Cytochrome P450 CYPD;
GN   Name=CYP704C1;
OS   Pinus taeda (Loblolly pine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Pinopsida; Pinidae; Conifers I; Pinales; Pinaceae; Pinus;
OC   Pinus subgen. Pinus.
OX   NCBI_TaxID=3352;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15911762; DOI=10.1073/pnas.0500825102;
RA   Ro D.-K., Arimura G., Lau S.Y.W., Piers E., Bohlmann J.;
RT   "Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a
RT   multifunctional, multisubstrate cytochrome P450 monooxygenase.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:8060-8065(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY779540; AAX07434.1; -; mRNA.
DR   AlphaFoldDB; Q50EK3; -.
DR   SMR; Q50EK3; -.
DR   OMA; LIMPTFN; -.
DR   BRENDA; 1.14.14.145; 4861.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..518
FT                   /note="Cytochrome P450 704C1"
FT                   /id="PRO_0000352516"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         461
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   518 AA;  59259 MW;  12E951F70765B28D CRC64;
     MDVNILTMFV TVSALALACS LWIASYLRNW RKKGVYPPVV GTMLNHAINF ERLHDYHTDQ
     AQRYKTFRVV YPTCSYVFTT DPVNVEHILK TNFANYDKGT FNYDIMKDLL GDGIFNVDGD
     KWRQQRKLAS SEFASKVLKD FSSGVFCNNA AKLANILAQA AKLNLSVEMQ DLFMRSSLDS
     ICKVVFGIDI NSLSSSKAES GPEASFAKAF DVANAMVFHR HMVGSFWKVQ RFFNVGSEAI
     LRDNIKMVDD FLYKVIHFRR QEMFSAEKEN VRPDILSRYI IISDKETDGK VSDKYLRDVI
     LNFMVAARDT TAIALSWFIY MLCKHQHVQE KLLEEIISST SVHEDQYSTE CNDIASFAQS
     LTDEALGKMH YLHASLSETL RLYPALPVDG KYVVNEDTLP DGFKVKKGDS VNFLPYAMGR
     MSYLWGDDAK EFKPERWIQD GIFHPKSPFK FPAFQAGPRT CLGKDFAYLQ MKIVAAVLVR
     FFKFEAVKTK EVRYRTMLTL HMNEDGLNVQ VTPRLNSD