C102A_HUMAN
ID C102A_HUMAN Reviewed; 550 AA.
AC Q96A19; Q9BT74;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Coiled-coil domain-containing protein 102A;
GN Name=CCDC102A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Placenta, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-28, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-28, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12 AND SER-28, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
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DR EMBL; AC004382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC004307; AAH04307.1; -; mRNA.
DR EMBL; BC008285; AAH08285.1; -; mRNA.
DR EMBL; BC009941; AAH09941.1; -; mRNA.
DR CCDS; CCDS10784.1; -.
DR RefSeq; NP_149989.2; NM_033212.3.
DR RefSeq; XP_011521771.1; XM_011523469.2.
DR AlphaFoldDB; Q96A19; -.
DR SMR; Q96A19; -.
DR BioGRID; 124987; 56.
DR IntAct; Q96A19; 23.
DR STRING; 9606.ENSP00000258214; -.
DR iPTMnet; Q96A19; -.
DR PhosphoSitePlus; Q96A19; -.
DR BioMuta; CCDC102A; -.
DR DMDM; 296434412; -.
DR EPD; Q96A19; -.
DR jPOST; Q96A19; -.
DR MassIVE; Q96A19; -.
DR MaxQB; Q96A19; -.
DR PaxDb; Q96A19; -.
DR PeptideAtlas; Q96A19; -.
DR PRIDE; Q96A19; -.
DR ProteomicsDB; 75892; -.
DR Antibodypedia; 48917; 110 antibodies from 24 providers.
DR DNASU; 92922; -.
DR Ensembl; ENST00000258214.3; ENSP00000258214.2; ENSG00000135736.6.
DR GeneID; 92922; -.
DR KEGG; hsa:92922; -.
DR MANE-Select; ENST00000258214.3; ENSP00000258214.2; NM_033212.4; NP_149989.2.
DR UCSC; uc002elw.4; human.
DR CTD; 92922; -.
DR DisGeNET; 92922; -.
DR GeneCards; CCDC102A; -.
DR HGNC; HGNC:28097; CCDC102A.
DR HPA; ENSG00000135736; Low tissue specificity.
DR neXtProt; NX_Q96A19; -.
DR OpenTargets; ENSG00000135736; -.
DR PharmGKB; PA144596469; -.
DR VEuPathDB; HostDB:ENSG00000135736; -.
DR eggNOG; ENOG502QSJ6; Eukaryota.
DR GeneTree; ENSGT00730000110960; -.
DR HOGENOM; CLU_033486_1_0_1; -.
DR InParanoid; Q96A19; -.
DR OMA; CWEVRSV; -.
DR OrthoDB; 1304833at2759; -.
DR PhylomeDB; Q96A19; -.
DR TreeFam; TF320856; -.
DR PathwayCommons; Q96A19; -.
DR SignaLink; Q96A19; -.
DR BioGRID-ORCS; 92922; 20 hits in 1076 CRISPR screens.
DR ChiTaRS; CCDC102A; human.
DR GenomeRNAi; 92922; -.
DR Pharos; Q96A19; Tdark.
DR PRO; PR:Q96A19; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96A19; protein.
DR Bgee; ENSG00000135736; Expressed in right coronary artery and 97 other tissues.
DR Genevisible; Q96A19; HS.
DR GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR InterPro; IPR002928; Myosin_tail.
DR Pfam; PF01576; Myosin_tail_1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..550
FT /note="Coiled-coil domain-containing protein 102A"
FT /id="PRO_0000274400"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 72..161
FT /evidence="ECO:0000255"
FT COILED 263..396
FT /evidence="ECO:0000255"
FT COILED 427..518
FT /evidence="ECO:0000255"
FT COMPBIAS 7..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..60
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..550
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 26
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231"
FT MOD_RES 28
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 537
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT CONFLICT 96
FT /note="R -> W (in Ref. 2; AAH08285/AAH09941)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 550 AA; 62596 MW; FB8D693B4B7E580A CRC64;
MSHGPSPRLA ESPQLSKGSL LTILGSPSPE RMGPADSLPP TPPSGTPSPG PPPALPLPPA
PALLADGDWE SREELRLREL EEARARAAQM EKTMRRWSDC TANWREKWSK VRAERNRARE
EVRQLRQRLD ALTKELAGAR RERQEAQGEC EARGRELARL RGARGVADQT RDGPEPEAER
EPVRDVGSER PPGSQELELV ESLLKSMPEE SEDCWEARSL GAGGPRGSSG RQERSRLPWE
DTAATEEEAS KLTALRLRLD ESQKVLLKER EDKLALSRNI EKLEGELSQW KIKYEELSKT
KQEMLKQLSI LKEAHQDELG RMSEDLEDEL GARSSMDRKM AELRGEMERL QAENAAEWGR
RERLETEKLG LERENKKLRA QVGDLEEALA RRRRQTASAL DCDLRASQAA LFEKNKELAD
LKHVHGKLKK QFQEKVAELA HANRRVEQHE AEVKKLRLRV EELKKELAQA EDELDEAHNQ
ARKLQRSLDE QTEQSENLQV QLEHLQSRLR RQQQNAPLFG KIRSARFGTE EAEDGTSDLD
EDEDLQIQVA
