ID   TRPB_KLEAE              Reviewed;          19 AA.
AC   P14552;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Tryptophan synthase beta chain;
DE            EC=4.2.1.20;
DE   Flags: Fragment;
GN   Name=trpB;
OS   Klebsiella aerogenes (Enterobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6262736; DOI=10.1093/nar/9.7.1743;
RA   Nichols B.P., Blumenberg M., Yanofsky C.;
RT   "Comparison of the nucleoside sequence of trpA and sequences immediately
RT   beyond the trp operon of Klebsiella aerogenes. Salmonella typhimurium and
RT   Escherichia coli.";
RL   Nucleic Acids Res. 9:1743-1755(1981).
CC   -!- FUNCTION: The beta subunit is responsible for the synthesis of L-
CC       tryptophan from indole and L-serine. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-
CC         glyceraldehyde 3-phosphate + H2O + L-tryptophan;
CC         Xref=Rhea:RHEA:10532, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384,
CC         ChEBI:CHEBI:57912, ChEBI:CHEBI:58866, ChEBI:CHEBI:59776; EC=4.2.1.20;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 5/5.
CC   -!- SUBUNIT: Tetramer of two alpha and two beta chains. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TrpB family. {ECO:0000305}.
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DR   EMBL; V00630; CAA23901.1; -; Genomic_DNA.
DR   EMBL; J01738; AAA25144.1; -; Genomic_DNA.
DR   AlphaFoldDB; P14552; -.
DR   STRING; 548.EAG7_01142; -.
DR   UniPathway; UPA00035; UER00044.
DR   GO; GO:0004834; F:tryptophan synthase activity; IEA:UniProtKB-EC.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Lyase;
KW   Pyridoxal phosphate; Tryptophan biosynthesis.
FT   CHAIN           <1..19
FT                   /note="Tryptophan synthase beta chain"
FT                   /id="PRO_0000098957"
FT   NON_TER         1
SQ   SEQUENCE   19 AA;  2183 MW;  82864627BF574E2C CRC64;
     RGDKDIFTVH DILKARGEI