C102A_MOUSE
ID C102A_MOUSE Reviewed; 549 AA.
AC Q3TMW1; A0AUL1; Q3B7Y4;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Coiled-coil domain-containing protein 102A;
GN Name=Ccdc102a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-549.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK165668; BAE38329.1; -; mRNA.
DR EMBL; BC107374; AAI07375.1; -; mRNA.
DR EMBL; BC107375; AAI07376.1; -; mRNA.
DR CCDS; CCDS22551.1; -.
DR RefSeq; NP_001028705.2; NM_001033533.3.
DR RefSeq; XP_011246656.1; XM_011248354.2.
DR AlphaFoldDB; Q3TMW1; -.
DR SMR; Q3TMW1; -.
DR BioGRID; 231542; 1.
DR IntAct; Q3TMW1; 1.
DR STRING; 10090.ENSMUSP00000077107; -.
DR iPTMnet; Q3TMW1; -.
DR PhosphoSitePlus; Q3TMW1; -.
DR EPD; Q3TMW1; -.
DR MaxQB; Q3TMW1; -.
DR PaxDb; Q3TMW1; -.
DR PRIDE; Q3TMW1; -.
DR ProteomicsDB; 273563; -.
DR Antibodypedia; 48917; 110 antibodies from 24 providers.
DR DNASU; 234582; -.
DR Ensembl; ENSMUST00000077955; ENSMUSP00000077107; ENSMUSG00000063605.
DR GeneID; 234582; -.
DR KEGG; mmu:234582; -.
DR UCSC; uc009mxh.2; mouse.
DR CTD; 92922; -.
DR MGI; MGI:2686927; Ccdc102a.
DR VEuPathDB; HostDB:ENSMUSG00000063605; -.
DR eggNOG; ENOG502QSJ6; Eukaryota.
DR GeneTree; ENSGT00730000110960; -.
DR HOGENOM; CLU_033486_1_0_1; -.
DR InParanoid; Q3TMW1; -.
DR OMA; CWEVRSV; -.
DR OrthoDB; 1304833at2759; -.
DR PhylomeDB; Q3TMW1; -.
DR TreeFam; TF320856; -.
DR BioGRID-ORCS; 234582; 4 hits in 70 CRISPR screens.
DR PRO; PR:Q3TMW1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3TMW1; protein.
DR Bgee; ENSMUSG00000063605; Expressed in humerus cartilage element and 217 other tissues.
DR ExpressionAtlas; Q3TMW1; baseline and differential.
DR Genevisible; Q3TMW1; MM.
DR GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR InterPro; IPR002928; Myosin_tail.
DR Pfam; PF01576; Myosin_tail_1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..549
FT /note="Coiled-coil domain-containing protein 102A"
FT /id="PRO_0000274401"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 69..160
FT /evidence="ECO:0000255"
FT COILED 263..398
FT /evidence="ECO:0000255"
FT COILED 426..517
FT /evidence="ECO:0000255"
FT COMPBIAS 7..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..58
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..549
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96A19"
FT MOD_RES 26
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96A19"
FT MOD_RES 28
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 536
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96A19"
FT CONFLICT 235
FT /note="R -> P (in Ref. 1; BAE38329)"
FT /evidence="ECO:0000305"
FT CONFLICT 442
FT /note="N -> H (in Ref. 1; BAE38329)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 549 AA; 62624 MW; 6E20BA327964E8BC CRC64;
MSHGPSPRLA ESPQLSKSSL LTILGSPSPE RMGPADSLPP TPPSGTPSPG PPPSLPLTAP
ALLADGDWES REELRLRELE EARARALQME KTMRWWSDCT ANWREKWSKV RAERNRAREE
VRQLRQRLDT LTKELAGARR ERQEAQGECE ARGRELARLR GVHSAADKTH DGPEPEREQE
PVRDIGAERP PGSQELDLVE SLLKSRPEEP EGCWDACSVA AGGPRVSSGR QDRNRLPWED
TASTEEDASK LTALRLRLDE SQKVLLKERE DKLALSKNIE KLEGELSQWK IKYEELSKTK
QEMLKQLSIL KETHQDELGR MSEDLEDELG ARSSMDRKMA ELRGEMERLQ AENAAEWGRR
ERLETEKLGL ERENKKLRAQ VGDLEEALAR RRRQNASALD CDLRASQAAL FEKNKELADL
KHVHGKLKKQ FQEKVAELAH ANRRVEQHET EVKKLRLRVE ELKKELAQAE DELDEAHNQA
RKLQRSLDEQ TEQSENLQVQ LEHLQSRLRR QQQNAPLFGK IRSTRFGTEE AGDGASDLDE
DEDLQIQVA
