ID   C10AA_BACTI             Reviewed;         675 AA.
AC   P09662;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Pesticidal crystal protein Cry10Aa;
DE   AltName: Full=78 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryXA(a);
GN   Name=cry10Aa; Synonyms=cryIVc, cryXA(a);
OS   Bacillus thuringiensis subsp. israelensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ONR60A;
RX   PubMed=3011746; DOI=10.1128/jb.166.3.801-811.1986;
RA   Thorne L., Garduno F., Thompson T., Decker D., Zounes M., Wild M.,
RA   Walfield A.M., Pollock T.J.;
RT   "Structural similarity between the lepidoptera- and diptera-specific
RT   insecticidal endotoxin genes of Bacillus thuringiensis subsp. 'kurstaki'
RT   and 'israelensis'.";
RL   J. Bacteriol. 166:801-811(1986).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of mosquitos. Active on Aedes aegypti.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; M12662; AAA22614.1; -; Genomic_DNA.
DR   PIR; B29838; B29838.
DR   AlphaFoldDB; P09662; -.
DR   SMR; P09662; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..675
FT                   /note="Pesticidal crystal protein Cry10Aa"
FT                   /id="PRO_0000174081"
SQ   SEQUENCE   675 AA;  77761 MW;  2A70011EEA7985F5 CRC64;
     MNPYQNKNEY EIFNAPSNGF SKSNNYSRYP LANKPNQPLK NTNYKDWLNV CQDNQQYGNN
     AGNFASSETI VGVSAGIIVV GTMLGAFAAP VLAAGIISFG TLLPIFWQGS DPANVWQDLL
     NIGGRPIQEI DKNIINVLTS IVTPIKNQLD KYQEFFDKWE PARTHANAKA VHDLFTTLEP
     IIDKDLDMLK NNASYRIPTL PAYAQIATWH LNLLKHAATY YNIWLQNQGI NPSTFNSSNY
     YQGYLKRKIQ EYTDYCIQTY NAGLTMIRTN TNATWNMYNT YRLEMTLTVL DLIAIFPNYD
     PEKYPIGVKS ELIREVYTNV NSDTFRTITE LENGLTRNPT LFTWINQGRF YTRNSRDILD
     PYDIFSFTGN QMAFTHTNDD RNIIWGAVHG NIISQDTSKV FPFYRNKPID KVEIVRHREY
     SDIIYEMIFF SNSSEVFRYS SNSTIENNYK RTDSYMIPKQ TWKNEEYGHT LSYIKTDNYI
     FSVVRERRRV AFSWTHTSVD FQNTIDLDNI TQIHALKALK VSSDSKIVKG PGHTGGDLVI
     LKDSMDFRVR FLKNVSRQYQ VRIRYATNAP KTTVFLTGID TISVELPSTT SRQNPNATDL
     TYADFGYVTF PRTVPNKTFE GEDTLLMTLY GTPNHSYNIY IDKIEFIPIT QSVLDYTEKQ
     NIEKTQKIVN DLFVN