C10_MOUSE
ID C10_MOUSE Reviewed; 126 AA.
AC O35127; Q545G8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein C10;
GN Name=Grcc10; Synonyms=C10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Ansari-Lari M.A., Oeltjen J.C., Schwartz S., Zhang Z., Muzny D.M., Lu J.,
RA Gorrell J.H., Chinault A.C., Belmont J.W., Miller W., Gibbs R.A.;
RT "Comparative sequence analysis of a gene-rich cluster at human chromosome
RT 12p13 and its syntetic region in mouse chromosome 6.";
RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=23453665; DOI=10.1016/j.ajhg.2013.01.008;
RA Zahrani F., Aldahmesh M.A., Alshammari M.J., Al-Hazzaa S.A., Alkuraya F.S.;
RT "Mutations in c12orf57 cause a syndromic form of colobomatous
RT microphthalmia.";
RL Am. J. Hum. Genet. 92:387-391(2013).
CC -!- FUNCTION: In brain, may be required for corpus callosum development.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed, with higher expression in
CC lung. {ECO:0000269|PubMed:23453665}.
CC -!- DEVELOPMENTAL STAGE: Detected as early as 10.5 dpc.
CC {ECO:0000269|PubMed:23453665}.
CC -!- SIMILARITY: Belongs to the UPF0456 family. {ECO:0000305}.
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DR EMBL; AC002397; AAC36004.1; -; Genomic_DNA.
DR EMBL; AK009591; BAB26379.1; -; mRNA.
DR EMBL; BC005683; AAH05683.1; -; mRNA.
DR CCDS; CCDS20525.1; -.
DR RefSeq; NP_038563.1; NM_013535.1.
DR AlphaFoldDB; O35127; -.
DR BioGRID; 200051; 3.
DR IntAct; O35127; 3.
DR MINT; O35127; -.
DR STRING; 10090.ENSMUSP00000004389; -.
DR iPTMnet; O35127; -.
DR PhosphoSitePlus; O35127; -.
DR EPD; O35127; -.
DR MaxQB; O35127; -.
DR PaxDb; O35127; -.
DR PeptideAtlas; O35127; -.
DR PRIDE; O35127; -.
DR ProteomicsDB; 273782; -.
DR Antibodypedia; 22799; 50 antibodies from 12 providers.
DR Ensembl; ENSMUST00000004389; ENSMUSP00000004389; ENSMUSG00000072772.
DR GeneID; 14790; -.
DR KEGG; mmu:14790; -.
DR UCSC; uc009drn.1; mouse.
DR CTD; 14790; -.
DR MGI; MGI:1315201; Grcc10.
DR VEuPathDB; HostDB:ENSMUSG00000072772; -.
DR eggNOG; ENOG502S2W0; Eukaryota.
DR GeneTree; ENSGT00390000005242; -.
DR HOGENOM; CLU_144250_1_0_1; -.
DR InParanoid; O35127; -.
DR OMA; GNDMMKM; -.
DR OrthoDB; 1599659at2759; -.
DR PhylomeDB; O35127; -.
DR TreeFam; TF323852; -.
DR BioGRID-ORCS; 14790; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Grcc10; mouse.
DR PRO; PR:O35127; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; O35127; protein.
DR Bgee; ENSMUSG00000072772; Expressed in embryonic brain and 172 other tissues.
DR Genevisible; O35127; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0048593; P:camera-type eye morphogenesis; ISO:MGI.
DR GO; GO:0050890; P:cognition; ISO:MGI.
DR GO; GO:0021540; P:corpus callosum morphogenesis; ISO:MGI.
DR GO; GO:0009791; P:post-embryonic development; ISO:MGI.
DR GO; GO:0036343; P:psychomotor behavior; ISO:MGI.
DR GO; GO:0014819; P:regulation of skeletal muscle contraction; ISO:MGI.
DR GO; GO:0021678; P:third ventricle development; ISO:MGI.
DR InterPro; IPR026317; P_C10.
DR PANTHER; PTHR13463; PTHR13463; 1.
DR Pfam; PF14974; P_C10; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q99622"
FT CHAIN 2..126
FT /note="Protein C10"
FT /id="PRO_0000065035"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q99622"
SQ SEQUENCE 126 AA; 13194 MW; 42659D346C7E290F CRC64;
MASASAQPAA LSAEQAKVVL AEVIQAFSAP ENAVRMDEAR DNACNDMGKM LQFVLPVATQ
IQQEVIKAYG FSCDGEGVLK FARLVKSYEA QDPEIASLSG KLKALFLPPM TLPPHGPASG
SSVAAS
