ID   C11AA_BACTI             Reviewed;         643 AA.
AC   P21256; Q79DX4;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Pesticidal crystal protein Cry11Aa;
DE   AltName: Full=72 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryXIA(a);
GN   Name=cry11Aa; Synonyms=cryD, cryIVd, cryXIA(a);
OS   Bacillus thuringiensis subsp. israelensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2902069; DOI=10.1128/jb.170.10.4732-4738.1988;
RA   Donovan W.P., Dankocsik C.C., Gilbert M.P.;
RT   "Molecular characterization of a gene encoding a 72-kilodalton mosquito-
RT   toxic crystal protein from Bacillus thuringiensis subsp. israelensis.";
RL   J. Bacteriol. 170:4732-4738(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 566-643.
RX   PubMed=2644205; DOI=10.1128/jb.171.1.521-530.1989;
RA   Adams L.F., Visick J.E., Whiteley H.R.;
RT   "A 20-kilodalton protein is required for efficient production of the
RT   Bacillus thuringiensis subsp. israelensis 27-kilodalton crystal protein in
RT   Escherichia coli.";
RL   J. Bacteriol. 171:521-530(1989).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of mosquitos.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; M31737; AAA22352.1; -; Genomic_DNA.
DR   EMBL; M22860; AAA22611.1; -; Genomic_DNA.
DR   PIR; A43647; A43647.
DR   RefSeq; WP_000390241.1; NZ_VEIF01000045.1.
DR   AlphaFoldDB; P21256; -.
DR   SMR; P21256; -.
DR   TCDB; 1.C.2.2.1; the channel-forming Delta-endotoxin insecticidal crystal protein (icp) family.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..643
FT                   /note="Pesticidal crystal protein Cry11Aa"
FT                   /id="PRO_0000174082"
SQ   SEQUENCE   643 AA;  72349 MW;  64CA35495409B74E CRC64;
     MEDSSLDTLS IVNETDFPLY NNYTEPTIAP ALIAVAPIAQ YLATAIGKWA AKAAFSKVLS
     LIFPGSQPAT MEKVRTEVET LINQKLSQDR VNILNAEYRG IIEVSDVFDA YIKQPGFTPA
     TAKGYFLNLS GAIIQRLPQF EVQTYEGVSI ALFTQMCTLH LTLLKDGILA GSAWGFTQAD
     VDSFIKLFNQ KVLDYRTRLM RMYTEEFGRL CKVSLKDGLT FRNMCNLYVF PFAEAWSLMR
     YEGLKLQSSL SLWDYVGVSI PVNYNEWGGL VYKLLMGEVN QRLTTVKFNY SFTNEPADIP
     ARENIRGVHP IYDPSSGLTG WIGNGRTNNF NFADNNGNEI MEVRTQTFYQ NPNNEPIAPR
     DIINQILTAP APADLFFKNA DINVKFTQWF QSTLYGWNIK LGTQTVLSSR TGTIPPNYLA
     YDGYYIRAIS ACPRGVSLAY NHDLTTLTYN RIEYDSPTTE NIIVGFAPDN TKDFYSKKSH
     YLSETNDSYV IPALQFAEVS DRSFLEDTPD QATDGSIKFA RTFISNEAKY SIRLNTGFNT
     ATRYKLIIRV RVPYRLPAGI RVQSQNSGNN RMLGSFTANA NPEWVDFVTD AFTFNDLGIT
     TSSTNALFSI SSDSLNSGEE WYLSQLFLVK ESAFTTQINP LLK