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TRPC1_BOVIN
ID   TRPC1_BOVIN             Reviewed;         793 AA.
AC   O18784; O18785;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Short transient receptor potential channel 1;
DE            Short=TrpC1;
DE   AltName: Full=Transient receptor protein 1;
DE            Short=TRP-1;
GN   Name=TRPC1; Synonyms=TRP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
RC   TISSUE=Aorta;
RX   PubMed=9357995; DOI=10.1016/s0014-5793(97)01155-1;
RA   Chang A.S., Chang S.M., Garcia R.L., Schilling W.P.;
RT   "Concomitant and hormonally regulated expression of trp genes in bovine
RT   aortic endothelial cells.";
RL   FEBS Lett. 415:335-340(1997).
CC   -!- FUNCTION: Thought to form a receptor-activated non-selective calcium
CC       permeant cation channel. Probably is operated by a phosphatidylinositol
CC       second messenger system activated by receptor tyrosine kinases or G-
CC       protein coupled receptors. Seems to be also activated by intracellular
CC       calcium store depletion.
CC   -!- SUBUNIT: Homotetramer and heterotetramer with TRPC4 and/or TRPC5 (By
CC       similarity). Interacts with TRPC4 and TRPC5 (By similarity). Interacts
CC       with ITPR3 (By similarity). Interacts with MX1 and RNF24 (By
CC       similarity). Interacts with FKBP4 (By similarity). Interacts with
CC       TRPC4AP (By similarity). Interacts with PLSCR1 (By similarity).
CC       {ECO:0000250|UniProtKB:P48995, ECO:0000250|UniProtKB:Q61056,
CC       ECO:0000250|UniProtKB:Q9QX01}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=O18784-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=O18784-2; Sequence=VSP_006559;
CC   -!- PTM: Activation of PRKCA induces phosphorylation of TRPC1 and
CC       subsequent Ca2+ entry into cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC       subfamily. TRPC1 sub-subfamily. {ECO:0000305}.
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DR   EMBL; AF012900; AAC48771.1; -; mRNA.
DR   EMBL; AF012901; AAC48772.1; -; mRNA.
DR   RefSeq; NP_776901.1; NM_174476.2. [O18784-1]
DR   AlphaFoldDB; O18784; -.
DR   SMR; O18784; -.
DR   STRING; 9913.ENSBTAP00000002887; -.
DR   PaxDb; O18784; -.
DR   GeneID; 282100; -.
DR   KEGG; bta:282100; -.
DR   CTD; 7220; -.
DR   eggNOG; KOG3609; Eukaryota.
DR   InParanoid; O18784; -.
DR   OrthoDB; 824310at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005457; TRPC1_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF56; PTHR10117:SF56; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01642; TRPCHANNEL1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ANK repeat; Calcium; Calcium channel;
KW   Calcium transport; Ion channel; Ion transport; Membrane; Phosphoprotein;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..793
FT                   /note="Short transient receptor potential channel 1"
FT                   /id="PRO_0000215302"
FT   TOPO_DOM        1..386
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        408..415
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        437..490
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        491..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        512..539
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        540..560
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        561..586
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        587..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        608..616
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        617..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        638..793
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          46..75
FT                   /note="ANK 1"
FT   REPEAT          83..111
FT                   /note="ANK 2"
FT   REPEAT          112..138
FT                   /note="ANK 3"
FT   REPEAT          158..187
FT                   /note="ANK 4"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         110..143
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000303|PubMed:9357995"
FT                   /id="VSP_006559"
SQ   SEQUENCE   793 AA;  91339 MW;  4A790FA203C0365B CRC64;
     MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY
     YMVKEILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL QLLLDYGCQS ADALLVAIDS
     EVVGAVDILL NHRPKRSSRP TIVKLMERIQ NPEYSTTMDV APVILAAHRN NYEILTMLLK
     QDVSLPKPHA VGCECTLCSA KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILGAFEL
     SADLKELSLV EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS NDEPLDKRGL
     LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK IMTVLTVGIF
     WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL LNLYSLVYHE DKKNTMGPAL
     ERIDYLLILW IIGMIWSDIK RLWYEGLEDF LEESRNQLSF VMNSLYLATF ALKEEAHNKF
     HDFADRKDWD AFHPTLVAEG LFAFANVLSY LRLFFYVYTS SILGPLQISM GRMLQDFGKF
     LGMFLLVLFS FTIGLTQLYD KGYTPKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS
     LAHVAILCTR FSYGEELQSF VGAFIVGTYN VVVVIVLTKL LVAMLHKSFQ LIANHEDKEW
     KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK WICSHTSKGK VKRQNSLKEW
     RHLNEKRDEN YQKVMCCLVR RYLTSMRQKM QSTDQATVEN LNELRQDLSK FRNEIRDLLG
     FRTSKYAMFY PRN
 
 
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