ID   TRPC1_STRCO             Reviewed;         269 AA.
AC   O68814; Q9S2U6;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 3.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Indole-3-glycerol phosphate synthase 1;
DE            Short=IGPS 1;
DE            EC=4.1.1.48;
GN   Name=trpC1; Synonyms=trpC; OrderedLocusNames=SCO2039; ORFNames=SC4G6.08c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=10361288; DOI=10.1046/j.1365-2958.1999.01407.x;
RA   Hu D.S.-J., Hood D.W., Heidstra R., Hodgson D.A.;
RT   "The expression of the trpD, trpC and trpBA genes of Streptomyces
RT   coelicolor A3(2) is regulated by growth rate and growth phase but not by
RT   feedback repression.";
RL   Mol. Microbiol. 32:869-880(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; AF054585; AAC63500.1; -; Genomic_DNA.
DR   EMBL; AL939111; CAB51431.1; -; Genomic_DNA.
DR   PIR; T35068; T35068.
DR   RefSeq; NP_626299.1; NC_003888.3.
DR   RefSeq; WP_011028110.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; O68814; -.
DR   SMR; O68814; -.
DR   STRING; 100226.SCO2039; -.
DR   GeneID; 1097473; -.
DR   KEGG; sco:SCO2039; -.
DR   PATRIC; fig|100226.15.peg.2070; -.
DR   eggNOG; COG0134; Bacteria.
DR   HOGENOM; CLU_034247_0_0_11; -.
DR   InParanoid; O68814; -.
DR   OMA; RGPHDLI; -.
DR   PhylomeDB; O68814; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IBA:GO_Central.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IBA:GO_Central.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IBA:GO_Central.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_A; IGPS_A; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..269
FT                   /note="Indole-3-glycerol phosphate synthase 1"
FT                   /id="PRO_0000154259"
FT   CONFLICT        29
FT                   /note="E -> V (in Ref. 1; AAC63500)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   269 AA;  28387 MW;  18688CF881D63967 CRC64;
     MSVLDEIIDG VRADLAERQA RVSLDELKER AAKARPAKDG VAALRGDGVK VICEVKRSSP
     SKGALAAIAD PAGLAADYEA GGAAVISVLT EERRFGGSLA DLDSVRARVD IPVLRKDFIV
     TSYQLWEARA HGADLVLLIV AALEQPALES LIERAESIGL TPLVEVHDED EVERAVDAGA
     KVIGVNARNL KTLEVDRGTF ERVAPEIPAH IVKVAESGVR GPHDLIAYAN EGADAVLVGE
     SLVTGRDPKT AVSDLVAAGE HPALRHGRS