ID   TRPC2_BOVIN             Reviewed;         432 AA.
AC   O62826;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Short transient receptor potential channel 2 homolog;
DE            Short=TrpC2;
DE   AltName: Full=Transient receptor protein 2;
DE            Short=TRP-2;
DE            Short=bTrp2;
GN   Name=TRPC2; Synonyms=TRP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=9657384; DOI=10.1016/s0014-5793(98)00561-4;
RA   Wissenbach U., Schroth G., Philipp S., Flockerzi V.;
RT   "Structure and mRNA expression of a bovine trp homologue related to
RT   mammalian trp2 transcripts.";
RL   FEBS Lett. 429:61-66(1998).
CC   -!- FUNCTION: Thought to form a receptor-activated calcium permeant cation
CC       channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC       subfamily. TRPC2 sub-subfamily. {ECO:0000305}.
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DR   EMBL; AJ006304; CAA06964.1; -; mRNA.
DR   AlphaFoldDB; O62826; -.
DR   SMR; O62826; -.
DR   STRING; 9913.ENSBTAP00000015344; -.
DR   PaxDb; O62826; -.
DR   eggNOG; KOG3609; Eukaryota.
DR   InParanoid; O62826; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005458; TRPC2_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF6; PTHR10117:SF6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01643; TRPCHANNEL2.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..432
FT                   /note="Short transient receptor potential channel 2
FT                   homolog"
FT                   /id="PRO_0000215309"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          356..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  48057 MW;  9BA438C22E98B02C CRC64;
     MVILSLYLAA FTLRLLLAGL AHKHCRDAPD GAACHYFTSA ERSEWRTEDP QFLAEVLFAV
     TSMLSFTRLA SILPAHESLG TLQISMGRMI DDMIRFMFIL MIILTAFLCG LNNIYVPYQE
     TERLGNFNET FQFLFWTMFG MEEHSVVDMP QFLVPEFVGR ALYGIFTIVM VIVLLNMLIA
     MITNSFQKIE DAADVEWKFA RSKLYLSYFR EGLTLPVPFN ILPSPKAIFY LLRRVFRFIC
     CCHFCCKTKK PDYPPIPTFA NPGAGAGPGE GERGSYRLRV IKALVQRYIE TAQREFEETR
     RKDLGNRLTE LTKTVSRLQS EVAGVQRAVV EAGPRRPPGG ASVLSRYITR VRNSFQNLGP
     PIPETPELTV PATVGTQESS EIGLPDAGGA QAPASGESGP SSPAHVLVHR EQESEGAGDL
     PQEADLGAKE GT