ID   TRPC2_RALSO             Reviewed;         268 AA.
AC   Q8XS01;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Indole-3-glycerol phosphate synthase 2;
DE            Short=IGPS 2;
DE            EC=4.1.1.48;
GN   Name=trpC2; OrderedLocusNames=RSp0680; ORFNames=RS01769;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OG   Plasmid megaplasmid Rsp.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; AL646053; CAD17831.1; -; Genomic_DNA.
DR   RefSeq; WP_011003978.1; NC_003296.1.
DR   AlphaFoldDB; Q8XS01; -.
DR   SMR; Q8XS01; -.
DR   STRING; 267608.RSp0680; -.
DR   EnsemblBacteria; CAD17831; CAD17831; RSp0680.
DR   GeneID; 60503596; -.
DR   KEGG; rso:RSp0680; -.
DR   eggNOG; COG0134; Bacteria.
DR   HOGENOM; CLU_034247_2_0_4; -.
DR   OMA; AGMHPAC; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000001436; Plasmid megaplasmid Rsp.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Plasmid; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..268
FT                   /note="Indole-3-glycerol phosphate synthase 2"
FT                   /id="PRO_0000154243"
SQ   SEQUENCE   268 AA;  28757 MW;  7E4BD95DDA2FE151 CRC64;
     MGILDAIKLG KEKEVAHAKT VRKLSGLEQA IKQRPPPRDF VGAVAERAGN GTVALIAEIK
     KASPSKGLIR SDFQVAAIAE AYRDGGAACL SVLTDQTFFQ GKPADLELAK AVSGLPVLRK
     DFMIDPYQVH EARAMGADAI LLILAMLDHG QAIELEAAAQ AMGMGVLIEI HDEPELERAM
     AMQSRLIGIN NRDLATFAAD LTTSERLASK VDRNRIVISE SGIGGHGDVI RLMEAGINGF
     LIGEQLLRAR HIESATREIA QARLHACP