ID   TRPC5_BOVIN             Reviewed;         109 AA.
AC   Q9MYV9;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Short transient receptor potential channel 5;
DE            Short=TrpC5;
DE   Flags: Fragment;
GN   Name=TRPC5; Synonyms=TRP5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=10816590; DOI=10.1074/jbc.m003408200;
RA   Philipp S., Trost C., Warnat J., Rautmann J., Himmerkus N., Schroth G.,
RA   Kretz O., Nastainczyk W., Cavalie A., Hoth M., Flockerzi V.;
RT   "TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like
RT   channels in adrenal cells.";
RL   J. Biol. Chem. 275:23965-23972(2000).
CC   -!- FUNCTION: Thought to form a receptor-activated non-selective calcium
CC       permeant cation channel. Probably is operated by a phosphatidylinositol
CC       second messenger system activated by receptor tyrosine kinases or G-
CC       protein coupled receptors. Has also been shown to be calcium-selective.
CC       May also be activated by intracellular calcium store depletion (By
CC       similarity). Mediates calcium-dependent phosphatidylserine
CC       externalization and apoptosis in neurons via its association with
CC       PLSCR1 (By similarity). {ECO:0000250|UniProtKB:Q9QX29,
CC       ECO:0000250|UniProtKB:Q9UL62}.
CC   -!- SUBUNIT: Homotetramer and heterotetramer with TRPC1 and/or TRPC4 (By
CC       similarity). Interacts with SLC9A3R1/NHERF (By similarity). Interacts
CC       with MX1 and RNF24 (By similarity). Interacts (via C-terminus) with
CC       CABP1 (By similarity). Interacts with SESTD1 (via the spectrin 1
CC       repeat) (By similarity). Interacts with TRPC4AP (By similarity).
CC       Interacts with PLSCR1 (By similarity). {ECO:0000250|UniProtKB:Q9QX29,
CC       ECO:0000250|UniProtKB:Q9UL62}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC       subfamily. TRPC5 sub-subfamily. {ECO:0000305}.
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DR   EMBL; AJ271070; CAC01678.1; -; mRNA.
DR   AlphaFoldDB; Q9MYV9; -.
DR   SMR; Q9MYV9; -.
DR   STRING; 9913.ENSBTAP00000013270; -.
DR   PaxDb; Q9MYV9; -.
DR   eggNOG; KOG3609; Eukaryota.
DR   HOGENOM; CLU_005716_4_1_1; -.
DR   InParanoid; Q9MYV9; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051402; P:neuron apoptotic process; ISS:UniProtKB.
DR   GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; ISS:UniProtKB.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005461; TRPC5_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF76; PTHR10117:SF76; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           <1..>109
FT                   /note="Short transient receptor potential channel 5"
FT                   /id="PRO_0000215317"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         109
SQ   SEQUENCE   109 AA;  12607 MW;  E0068E440512BAC9 CRC64;
     FIYCLVLLAF ANGLNQLYFY YETRAIDEPN NCKGIRCEKQ NNAFSTLFET LQSLFWSVFG
     LLNLYVTNVK ARHEFTEFVG ATMFGTYNVI SLVVLLNMLI AMMNNSYQL