TRPCG_DROME
ID TRPCG_DROME Reviewed; 2023 AA.
AC A8DYE2; A1Z9Z5; Q0E967; Q7K1C1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Transient receptor potential cation channel trpm;
DE AltName: Full=Transient receptor potential cation channel, subfamily M ortholog;
GN Name=Trpm; ORFNames=CG44240;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP RNA EDITING OF POSITIONS 1684; 1860; 1900; 1915 AND 1917.
RX PubMed=17018572; DOI=10.1261/rna.254306;
RA Stapleton M., Carlson J.W., Celniker S.E.;
RT "RNA editing in Drosophila melanogaster: new targets and functional
RT consequences.";
RL RNA 12:1922-1932(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-858, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Calcium channel mediating constitutive calcium ion entry.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=E;
CC IsoId=A8DYE2-1; Sequence=Displayed;
CC Name=B;
CC IsoId=A8DYE2-2; Sequence=VSP_052814, VSP_052815, VSP_052818,
CC VSP_052819;
CC Name=C;
CC IsoId=A8DYE2-3; Sequence=VSP_052814, VSP_052815, VSP_052816,
CC VSP_052817;
CC Name=D;
CC IsoId=A8DYE2-4; Sequence=VSP_052814, VSP_052815;
CC -!- RNA EDITING: Modified_positions=1684 {ECO:0000269|PubMed:17018572},
CC 1860 {ECO:0000269|PubMed:17018572}, 1900 {ECO:0000269|PubMed:17018572},
CC 1915 {ECO:0000269|PubMed:17018572}, 1917 {ECO:0000269|PubMed:17018572};
CC Note=Partially edited. Target of Adar.;
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC
CC subfamily. {ECO:0000305}.
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DR EMBL; AE013599; AAF58153.2; -; Genomic_DNA.
DR EMBL; AE013599; AAM68528.1; -; Genomic_DNA.
DR EMBL; AE013599; ABI31097.1; -; Genomic_DNA.
DR EMBL; AE013599; ABV53803.1; -; Genomic_DNA.
DR EMBL; AY069181; AAL39326.1; -; mRNA.
DR RefSeq; NP_001036548.1; NM_001043083.2. [A8DYE2-2]
DR RefSeq; NP_001036549.1; NM_001043084.2. [A8DYE2-4]
DR RefSeq; NP_001036550.2; NM_001043085.2.
DR RefSeq; NP_001097320.1; NM_001103850.2. [A8DYE2-1]
DR AlphaFoldDB; A8DYE2; -.
DR SMR; A8DYE2; -.
DR BioGRID; 62431; 3.
DR IntAct; A8DYE2; 4.
DR STRING; 7227.FBpp0112395; -.
DR TCDB; 1.A.4.5.9; the transient receptor potential ca(2+) channel (trp-cc) family.
DR iPTMnet; A8DYE2; -.
DR PaxDb; A8DYE2; -.
DR PRIDE; A8DYE2; -.
DR DNASU; 36694; -.
DR EnsemblMetazoa; FBtr0339075; FBpp0308221; FBgn0265194. [A8DYE2-2]
DR EnsemblMetazoa; FBtr0339076; FBpp0308222; FBgn0265194. [A8DYE2-4]
DR EnsemblMetazoa; FBtr0339077; FBpp0308223; FBgn0265194. [A8DYE2-1]
DR GeneID; 36694; -.
DR KEGG; dme:Dmel_CG44240; -.
DR UCSC; CG34123-RB; d. melanogaster. [A8DYE2-1]
DR CTD; 36694; -.
DR FlyBase; FBgn0265194; Trpm.
DR VEuPathDB; VectorBase:FBgn0265194; -.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000168570; -.
DR InParanoid; A8DYE2; -.
DR OMA; YAIAYIC; -.
DR PhylomeDB; A8DYE2; -.
DR Reactome; R-DME-3295583; TRP channels.
DR BioGRID-ORCS; 36694; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 36694; -.
DR PRO; PR:A8DYE2; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0265194; Expressed in saliva-secreting gland and 25 other tissues.
DR ExpressionAtlas; A8DYE2; baseline and differential.
DR Genevisible; A8DYE2; DM.
DR GO; GO:0034703; C:cation channel complex; IDA:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IDA:FlyBase.
DR GO; GO:0097682; F:intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity; IDA:FlyBase.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:FlyBase.
DR GO; GO:0098655; P:cation transmembrane transport; IDA:FlyBase.
DR GO; GO:0010960; P:magnesium ion homeostasis; IMP:FlyBase.
DR GO; GO:0030001; P:metal ion transport; IDA:FlyBase.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR GO; GO:0055069; P:zinc ion homeostasis; IMP:FlyBase.
DR Gene3D; 1.20.5.1010; -; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Ion channel; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; RNA editing; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..2023
FT /note="Transient receptor potential cation channel trpm"
FT /id="PRO_0000341487"
FT TOPO_DOM 1..653
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 675..927
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 928..948
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 949..992
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 993..1013
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1014..1024
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1025..1045
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1046..1057
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1058..1078
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1079..1136
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1137..1157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1158..2023
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 56..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1471..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1556..1585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1698..1734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1751..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1814..1844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1874..1904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1919..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1962..1990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2003..2023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 858
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 1..9
FT /note="MVVTDSPLA -> MYFETNWVF (in isoform B, isoform C and
FT isoform D)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_052814"
FT VAR_SEQ 10..111
FT /note="Missing (in isoform B, isoform C and isoform D)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_052815"
FT VAR_SEQ 1173..1180
FT /note="WMFQRFTV -> SVIESLRF (in isoform C)"
FT /evidence="ECO:0000305"
FT /id="VSP_052816"
FT VAR_SEQ 1181..2023
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000305"
FT /id="VSP_052817"
FT VAR_SEQ 1214..1233
FT /note="LEVQRDNGLKLFLEKDDLER -> EPGMSKFSFVPCESIVSDAL (in
FT isoform B)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_052818"
FT VAR_SEQ 1234..2023
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_052819"
FT VARIANT 1684
FT /note="I -> M (in RNA edited version)"
FT VARIANT 1860
FT /note="T -> A (in RNA edited version)"
FT VARIANT 1900
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 1915
FT /note="Q -> R (in RNA edited version)"
FT VARIANT 1917
FT /note="S -> G (in RNA edited version)"
SQ SEQUENCE 2023 AA; 225538 MW; 0B95069ECE8E67F3 CRC64;
MVVTDSPLAP HKYVRRISKD FSTVRRYSNT PAVVVGSFRA STSAFIAAES AAHLPTCSSP
TTRTPVSTPR GIRRRQRMRK RSSVSSTLSK VLILNVRDLL KAHAGSEPLK EHQPRSWIET
NFQKRECIKF IPCPKDDTKC CCGQAQITHQ TIPGIESGSP GDLWLPTKHT RPQPTDAYGT
IEFQGGAHPT KAQYVRLSFD TRPELLVQLF TKEWNLELPK LLITVQGGKA NFDLQAKLKK
EIRKGLLKAA KTTGAWIFTG GTNTGVTKQV GDALLLEGQQ RTGRVVSIGI APWGIVERNH
ELLGHNREVP CHSISSPRSK LAVLNNRHAY FLLVDNGTQA KYGAELILRR KLEKFISNLK
LHPFTHSSTP VVCLVIEGGT NTIRAVLEYV TDSPPVPVVV CDGSGRAADL LAFVHKYASD
GEEQPVLESM RDYLIGTIQK TFEVGLDQSE KLYQELLQCT RNKNLITVFR IQEKPEGEAQ
ELDQTILTAL FKSQHLSPPE QLSLALTWNR VDIARSEIFV YGQEWPNGAL DEAMMQALEH
DRIDFVKLLL ENGVSMKKFL TIPRLEELYN TKHGPANTLG YILRDVRPHI PKGYIYTLHD
IGLVINKLMG GAYRSYYTRR KFRPIYAKVM NSYANACRKS STYQYQRYAG ANSLSLVTGL
LPFTSEMALF EFPFNELLIW AVLTKRQQMA LLMWTHGEEA LAKSLVSCKL YKAMAHEAAE
DDLDTEIYEE LRSYAKEFES KGNKLLDFSY RQDAEKAQRL LTCELHSWSN QSCLSLAVAA
NHRALLAHPC SQVILADLWM GGLRTRKNTN FKVILGLAMP FYIRQLDFKS KEELQQMPQT
EEEHLENQNL DNDDSDRSQP DAEALLADTY SVRDTKVHEN GKVSLTDSDT AQFREFFNLS
EYNEVKQHQP LRLKKKFYEF YTAPITKFWA DSIAYMFFLI MFSFTVLVKM EQMPRWQEWY
SIAYITTLGF EKVREIISSE PVAITHKFSV WAWNMWNPCD GAAIILFVIG LAFRFRENTM
DIGRVIYCVD SIYWYLRILN ILGVNKYLGP LVTMMGKMVK NMIYFVVLLA VVLMSFGVSR
QAILYPNKQP TWSLIKEVTF QPYFMLYGEV FAGDIDPPCG EDPSQPGCVT GHWVTPITMS
MYLLIANILL INLLIAVFNN IFNEVNSVSH QVWMFQRFTV VMEYQQKPVL PPPFIALCHF
YSLLKYCVRK AKGLEVQRDN GLKLFLEKDD LERLYDFEEE CVEGFFHEQE IILNQSTDER
VKNTTERVET MSQKIEDINQ KENIQTATVQ NIEFRLRKME ESSEQILSHL AVIHRFMSTH
TAGADDLRGS TINIPGEMQR MRTISISDTE GGSGPGGNGG GGGGGGAIVP LGLGAGLNLN
SLQVTTRRRF NRSLTEVRPD AYIFDEGTHF EVVPLPEEPD EVVKSREALN EQVVRKASMQ
SEADSDIYIP VSQRPSTCET VKRTPYVTVR QDTGASTESK DTLTPMGNND DDQTLVGGDN
SDDATPDINF EAARHRALRQ RTVSLCRRNS ETYSLTGADI NRSHISLNQL ASLSRRQMSL
TQSEPDSDKD APIAQGSAHP GKSVLHAKPS RNILLKLHSE YTSITDELES VCHMIASPTV
SLPSNKASLD RPKTEMSRAE AAALLEKKHL KECEENDYMI LEGLIESRGS IDASAQGFEI
GVSIDYSHRY PLRRETAVEL SPSKPSVDGD LMGGGEGGGA GGGDSSDTSG AGSCGAMVGI
SSGFQLKNER PWQRNSSMEQ QTYPSPLVPT RATSDFLNPP YEGRLFKKSS ESLQKNSSTE
TDYSAHPYRF IKQSSNETNT SLTGSYNVDT PSLTAEPSLD AGDSHSATGI SISVGAVGGT
ATARYQPIRT ASVGAADGRR LREESSSSLD LSSSGPVTMQ AAPAPPVRPM LLKKQFSVDQ
GKPSQTAAEA VPQTPEAAQA GQAKLISTLK PQPFASKLGM NVLKESSSST DESVGSSAKS
SNPALSIPQI STHLVQDEIA KLSSNIKSST ESEKDPPFNE TMC
