TRPC_ACIAD
ID TRPC_ACIAD Reviewed; 268 AA.
AC P00911; Q6F9N1;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Indole-3-glycerol phosphate synthase;
DE Short=IGPS;
DE EC=4.1.1.48;
GN Name=trpC; OrderedLocusNames=ACIAD2463;
OS Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=62977;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6599977; DOI=10.1093/oxfordjournals.molbev.a040331;
RA Kaplan J.B., Goncharoff P., Seibold A.M., Nichols B.P.;
RT "Nucleotide sequence of the Acinetobacter calcoaceticus trpGDC gene
RT cluster.";
RL Mol. Biol. Evol. 1:456-472(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33305 / BD413 / ADP1;
RX PubMed=15514110; DOI=10.1093/nar/gkh910;
RA Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT a versatile and naturally transformation competent bacterium.";
RL Nucleic Acids Res. 32:5766-5779(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5.
CC -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG69233.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M36636; AAA21905.1; -; Genomic_DNA.
DR EMBL; CR543861; CAG69233.1; ALT_INIT; Genomic_DNA.
DR PIR; A01133; GWKECC.
DR RefSeq; WP_004928449.1; NC_005966.1.
DR AlphaFoldDB; P00911; -.
DR SMR; P00911; -.
DR STRING; 62977.ACIAD2463; -.
DR EnsemblBacteria; CAG69233; CAG69233; ACIAD2463.
DR GeneID; 45234768; -.
DR KEGG; aci:ACIAD2463; -.
DR eggNOG; COG0134; Bacteria.
DR HOGENOM; CLU_034247_2_0_6; -.
DR OrthoDB; 1789381at2; -.
DR BioCyc; ASP62977:ACIAD_RS11255-MON; -.
DR UniPathway; UPA00035; UER00043.
DR Proteomes; UP000000430; Chromosome.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00134_B; IGPS_B; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854; PTHR22854; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR PROSITE; PS00614; IGPS; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW Lyase; Reference proteome; Tryptophan biosynthesis.
FT CHAIN 1..268
FT /note="Indole-3-glycerol phosphate synthase"
FT /id="PRO_0000154205"
FT CONFLICT 72
FT /note="A -> V (in Ref. 1; AAA21905)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 268 AA; 30189 MW; 50C41B42DBDE68AE CRC64;
MIQIQNTILG KIVDRKHEEL ADRLKQRNLK DVEQWVKEAP PVRGFAQSLR SKRPGVIAEI
KKASPSKGVI RADFNPAEIA QQYEQAGAAC LSVLTDVDFF QGADENIAIA RQHCSLPALR
KDFLIDPYNV VEARALQADC ILLIVACLSD QQLEEMSKTA FEYDLDVLVE VHDEQELERA
LKLSEQCLLG VNNRNLKTFD VDLNTSLRLK KLLDPSRLLV TESGIATPQD VQLMQEHDIH
SFLVGESFMK QPRPDQAFTE LFGVPKLV
