ID   TRPC_AZOBR              Reviewed;         262 AA.
AC   P26938;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC;
OS   Azospirillum brasilense.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Azospirillaceae; Azospirillum.
OX   NCBI_TaxID=192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29145 / DSM 1690 / IMET 11303 / Sp7;
RX   PubMed=1896020; DOI=10.1007/bf00264211;
RA   Zimmer W., Aparicio C., Elmerich C.;
RT   "Relationship between tryptophan biosynthesis and indole-3-acetic acid
RT   production in Azospirillum: identification and sequencing of a trpGDC
RT   cluster.";
RL   Mol. Gen. Genet. 229:41-51(1991).
CC   -!- FUNCTION: Participates in the tryptophan-dependent indole-3-acetic acid
CC       production, which is a phytohormone released by A.brasilense.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; X57853; CAA40986.1; -; Genomic_DNA.
DR   PIR; S17705; S17705.
DR   AlphaFoldDB; P26938; -.
DR   SMR; P26938; -.
DR   UniPathway; UPA00035; UER00043.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Tryptophan biosynthesis.
FT   CHAIN           1..262
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154207"
SQ   SEQUENCE   262 AA;  28123 MW;  A4CA5CDEAD299927 CRC64;
     MSDVLTRICD DKRALVQARK SARPLSAVED DARSADPAGG FIRALRRTVD GGRYGLIAEI
     KKASPSKGLI RPDFDPPSLA RAYRGGGATC LSVLTDEPYF QGCDDYLLSA RAAVDLPVLR
     KDFMVDPYQI AESRALGADC ILIIMAALSD AQAVEIEDAA IAWGLDVLVE VHNREELDRA
     LALKTPLLGV NNRNLKTLAV DIATTEELAA HVPADRMLVA ESGLYSPADL SRMAAVGARC
     FLVGESLMRQ EDVSAATRAL LA