ID   C11BB_BACTV             Reviewed;         750 AA.
AC   Q9ZIU5;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Pesticidal crystal protein Cry11Bb;
DE   AltName: Full=84 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryXIB(b);
GN   Name=cry11Bb; Synonyms=cryXIB(b);
OS   Bacillus thuringiensis subsp. medellin.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=79672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CIB 163-131;
RX   PubMed=9774743; DOI=10.1016/s0167-4838(98)00168-x;
RA   Orduz S., Realpe M., Arango R., Murillo L.A., Delecluse A.;
RT   "Sequence of the cry11Bb11 gene from Bacillus thuringiensis subsp. medellin
RT   and toxicity analysis of its encoded protein.";
RL   Biochim. Biophys. Acta 1388:267-272(1998).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of mosquito larvae such as Aedes aegypti, Anopheles
CC       albimanus and Culex quinquefasciatus.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; AF017416; AAC97162.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9ZIU5; -.
DR   SMR; Q9ZIU5; -.
DR   TCDB; 1.C.2.2.3; the channel-forming Delta-endotoxin insecticidal crystal protein (icp) family.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..750
FT                   /note="Pesticidal crystal protein Cry11Bb"
FT                   /id="PRO_0000174084"
FT   REGION          672..750
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   750 AA;  84408 MW;  293C383018B33D46 CRC64;
     MENNSFNVLA NNNMSSFPLF NSKIEPSIAP ALIAVAPIAK YLATALAKWA LKQGFAKLKS
     EIFPGNETAT MEKVRLEVQT ILNQTLQTDR VATLKAEYEG FIHLGKVFTD YVSQSTFTPA
     TAKTHFLNMS NLLIQRLPQF EIAGYEGVSI SLFTQMCTLH LGLLKDGILA GSDWGFTPED
     KDSLICQFNR YVNEYNTRMM GLYSIEFGRL LAKNLNEALN FRNMCSLYVF PFSEAWYLLR
     YEGTKLENTL SLWNFVGEDI GGILHNDWKG ALYKLLMGAT NQRLANVRFN YSYFSDTQGT
     IHRENILGAH PTYNGEQTPT GWIGNGRLGR FSAPYSNELE ITKVEQEITY NNKGDHSNSI
     VPANTRNEIL TATVPITADP FFKTADINWR YFSQGLYYGW NIKFDDRVIL NSRVPGGIPS
     NRLEYDGYYI RAVSACPRNV PLSYNHNYLT LTYNRLEYDA PTTQNIIVGF SPNNTKSFYA
     RNSHYLSATN DAYVIPALQF ATVSDRSFLE DTPDQATDGS IKFTETVLGN EAKYSIRLNT
     GFNTATRYRL VIRFKATARL AAGIRVRSQN SGNNRLLGGI PVEGNSGWVD YITDSFTFND
     LGITTASTNA FFSIDSDGVN ASQQWYLSKL ILVKDFVNNS GFRNQVPLAP YVIARCPNTF
     FVSNNTSSGY EQGYNDNYNQ NTSSGYEQGY NDNYNQNTSS GYEQGYNDNY NQNTSSGYEQ
     GYNDNYNQNT SSGYEQGYND NYNQNTSSGV