ID   TRPC_BACPU              Reviewed;          68 AA.
AC   P18268;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
DE   Flags: Fragment;
GN   Name=trpC;
OS   Bacillus pumilus (Bacillus mesentericus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1408;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RUB502;
RX   PubMed=2110100; DOI=10.1016/0378-1119(90)90497-f;
RA   Rivas M.V., Jarvis E.D., Rudner R.;
RT   "The structure of the trpE, trpD and 5' trpC genes of Bacillus pumilus.";
RL   Gene 87:71-78(1990).
RN   [2]
RP   ERRATUM OF PUBMED:2110100.
RX   PubMed=2227447; DOI=10.1016/0378-1119(90)90483-8;
RA   Rivas M.V., Jarvis E.D., Rudner R.;
RL   Gene 94:141-143(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; M36468; AAB02274.1; -; Genomic_DNA.
DR   PIR; JH0100; JH0100.
DR   AlphaFoldDB; P18268; -.
DR   SMR; P18268; -.
DR   UniPathway; UPA00035; UER00043.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Tryptophan biosynthesis.
FT   CHAIN           1..>68
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154212"
FT   NON_TER         68
SQ   SEQUENCE   68 AA;  7688 MW;  DFDDBEFC80E7BDE4 CRC64;
     MLNQIIARKK EHIQTLQLPV DGHFERRSFK EALMNPHRSI GLIAEVKKAS PSKGIIQPNF
     DPLQTAKA