ID   TRPC_BRADU              Reviewed;         273 AA.
AC   P94327;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   28-FEB-2003, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=blr4810;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=9061023; DOI=10.1016/s0167-4781(96)00237-0;
RA   Kuykendall L.D., Hunter W.J.;
RT   "The sequence of a symbiotically essential Bradyrhizobium japonicum operon
RT   consisting of trpD, trpC and a moaC-like gene.";
RL   Biochim. Biophys. Acta 1350:277-281(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; U79771; AAB39010.1; -; Genomic_DNA.
DR   EMBL; BA000040; BAC50075.1; -; Genomic_DNA.
DR   PIR; T46959; T46959.
DR   RefSeq; NP_771450.1; NC_004463.1.
DR   RefSeq; WP_011087578.1; NZ_CP011360.1.
DR   AlphaFoldDB; P94327; -.
DR   SMR; P94327; -.
DR   STRING; 224911.27353074; -.
DR   EnsemblBacteria; BAC50075; BAC50075; BAC50075.
DR   GeneID; 64024564; -.
DR   KEGG; bja:blr4810; -.
DR   PATRIC; fig|224911.44.peg.4649; -.
DR   eggNOG; COG0134; Bacteria.
DR   HOGENOM; CLU_034247_2_0_5; -.
DR   InParanoid; P94327; -.
DR   OMA; RGPHDLI; -.
DR   PhylomeDB; P94327; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IBA:GO_Central.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IBA:GO_Central.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IBA:GO_Central.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..273
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154215"
FT   CONFLICT        79
FT                   /note="L -> F (in Ref. 1; AAB39010)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        146
FT                   /note="A -> T (in Ref. 1; AAB39010)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   273 AA;  29373 MW;  7662A92C23FF0613 CRC64;
     MSDILTKIET YKREEIAAAK RAQPLSVVEA TAKAQGAPRG FLRAIKAKHT NGDFALIAEV
     KKASPSKGLI RADFDPPQLA KAYEAGGAAC LSVLTDTPSF QGHLDFMVAA RAATSLPVLR
     KDFMFDAYQV VEARAHGADC ILIIMAALDD ATAKDLEDTA IAFGMDVLIE IHDRAELDRA
     LKLRSPMIGV NNRNLRTFET TLATSEALAP LIPGDRLMVG ESGIFTPADL ARLERVGMST
     FLVGESLMRQ ADVTAATRTL LARETTARAT GTR