ID   C12A2_MUSDO             Reviewed;         537 AA.
AC   O18635;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Cytochrome P450 CYP12A2;
DE            EC=1.14.-.-;
DE   AltName: Full=CYPXIIA2;
GN   Name=CYP12A2;
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Rutgers;
RA   Guzov V.M., Feyereisen R.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; U94698; AAC98527.1; -; mRNA.
DR   RefSeq; NP_001295932.1; NM_001309003.1.
DR   AlphaFoldDB; O18635; -.
DR   SMR; O18635; -.
DR   PRIDE; O18635; -.
DR   GeneID; 101889857; -.
DR   KEGG; mde:101889857; -.
DR   CTD; 101889857; -.
DR   VEuPathDB; VectorBase:MDOA006998; -.
DR   eggNOG; KOG0159; Eukaryota.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase.
FT   CHAIN           1..537
FT                   /note="Cytochrome P450 CYP12A2"
FT                   /id="PRO_0000051923"
FT   BINDING         483
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   537 AA;  61709 MW;  20BFE40CF965A82A CRC64;
     MLKTKQQIIA LNRFRCWTSN LPGLQQQCRN QSTVTAASSE WEQAKPLSEM PTISPFQLLR
     HFLPGGKYTN LDTTQLMLAF RRDFGPIVYF KGSLGKPDVV MTNNPHDFEK ALHNQGIWPM
     RPGMEYLSYH RQVHRKDIFQ GVEGLLGSQG EAWGSFRSAV NPVLMQPKNV HLYFNKMSEV
     NKEFMERIRK IRDPQTLEVP DNFEEEINRW TLESVSVVAL DKQLGLITKN RDDPTPKRLF
     KALTDFFEAS GDLEFQPSIW KYIKTPTFKK AIRSLDEITD ITKMYVDEAF ERIEAENKNR
     NVEKPENEKS VLEKLVKIDK QIAMVMAMDM LMAGVDTTSS TFTGLLLCLA KNPEKQKKLR
     EEIMQLLPQK DSEFNEAVFK NMPYLRACIK ESLRVYPLTV GNARTQANDV VISGYRVPKG
     TLISMNSVTL IKDDAHYPRA SEFLPERWLR ASKENEKSAE CPHALKASSP FVYLPFGFGS
     RSCIGRRIAE MELELGIARL IRNFHVEFNY PTDNAFKSLL ISVPNIPLKF KFTDVDN