ID   TRPC_CAUVN              Reviewed;         262 AA.
AC   B8GWP9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE            Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE            EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN   Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134}; OrderedLocusNames=CCNA_01976;
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00134};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
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DR   EMBL; CP001340; ACL95441.1; -; Genomic_DNA.
DR   RefSeq; WP_010919765.1; NC_011916.1.
DR   RefSeq; YP_002517349.1; NC_011916.1.
DR   AlphaFoldDB; B8GWP9; -.
DR   SMR; B8GWP9; -.
DR   PRIDE; B8GWP9; -.
DR   EnsemblBacteria; ACL95441; ACL95441; CCNA_01976.
DR   GeneID; 7330116; -.
DR   KEGG; ccs:CCNA_01976; -.
DR   PATRIC; fig|565050.3.peg.1934; -.
DR   HOGENOM; CLU_034247_2_0_5; -.
DR   OMA; RGPHDLI; -.
DR   OrthoDB; 1789381at2; -.
DR   PhylomeDB; B8GWP9; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..262
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_1000198770"
SQ   SEQUENCE   262 AA;  27671 MW;  DF65E36277AAD4C3 CRC64;
     MTDILAKIAA YKREDVAARK AERSQAEIDA AAKAASAPRG FKAALEAHHA PGRLSLIAEI
     KKASPSKGLI REDFDPPVLA KAYEAGGAAC LSVLTDGPSF QGADDYLVTA RAAVALPCIR
     KDFLVDPWQV AESRALGADA ILVILAMIDD VLAAELMSEA RRLGMDALVE VHDEAEMARA
     GALGSDLVGI NNRDLKSFVV DLAVTERLSA QAPRDALLVT ESGIFTHDDV VRMEATGAKA
     MLVGESLMRH ADVTSATRAL IA