ID   TRPC_CERS4              Reviewed;         270 AA.
AC   Q9ZFA7; Q3J4Y4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=RHOS4_05820; ORFNames=RSP_6214;
OS   Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS   31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=272943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10511537; DOI=10.1093/genetics/153.2.525;
RA   Mackenzie C., Simmons A.E., Kaplan S.;
RT   "Multiple chromosomes in bacteria. The yin and yang of trp gene
RT   localization in Rhodobacter sphaeroides 2.4.1.";
RL   Genetics 153:525-538(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC   / NCIMB 8253 / ATH 2.4.1.;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA   Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; AF108766; AAD09119.1; -; Genomic_DNA.
DR   EMBL; CP000143; ABA78150.1; -; Genomic_DNA.
DR   PIR; T46856; T46856.
DR   RefSeq; WP_011337146.1; NZ_CP030271.1.
DR   RefSeq; YP_352051.1; NC_007493.2.
DR   AlphaFoldDB; Q9ZFA7; -.
DR   SMR; Q9ZFA7; -.
DR   STRING; 272943.RSP_6214; -.
DR   EnsemblBacteria; ABA78150; ABA78150; RSP_6214.
DR   KEGG; rsp:RSP_6214; -.
DR   PATRIC; fig|272943.9.peg.889; -.
DR   eggNOG; COG0134; Bacteria.
DR   OMA; RGPHDLI; -.
DR   PhylomeDB; Q9ZFA7; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000002703; Chromosome 1.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..270
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154248"
SQ   SEQUENCE   270 AA;  29220 MW;  C89F2CBC497A355C CRC64;
     MSTILDRIKA YKLEEIAARK AERPLVAVED AARAAPAPRG FARALSTAAA TGYGLIAEIK
     KASPSKGLIR EDFDVPALAR AYETGGATCL SVLTDGPSFQ GADDFLRQAR EAVKLPCLRK
     DFLYDTYQVA EARALGADCI LIIMASVTDS QALELEAAAS HWGMDVLVEV HSREELARAE
     HLKSRLIGIN NRNLDTFEVS LDVTRDLARR VPEDRLIVSE SGLHTPEDLA DLARYGARCF
     LIGESLMRQA DVEAATRAIL ADPLTAQGGV