ID   TRPC_LACCA              Reviewed;         260 AA.
AC   P17217;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC;
OS   Lactobacillus casei.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=1582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2113923; DOI=10.1093/oxfordjournals.jbchem.a123034;
RA   Natori Y., Kano Y., Imamoto F.;
RT   "Nucleotide sequences and genomic constitution of five tryptophan genes of
RT   Lactobacillus casei.";
RL   J. Biochem. 107:248-255(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; D00496; BAA00384.1; -; Genomic_DNA.
DR   PIR; S42344; JS0341.
DR   RefSeq; WP_016382180.1; NZ_JDWK01000136.1.
DR   AlphaFoldDB; P17217; -.
DR   SMR; P17217; -.
DR   STRING; 543734.LCABL_00750; -.
DR   eggNOG; COG0134; Bacteria.
DR   UniPathway; UPA00035; UER00043.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Tryptophan biosynthesis.
FT   CHAIN           1..260
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154224"
SQ   SEQUENCE   260 AA;  28944 MW;  47F5722735A1BEB8 CRC64;
     MILDDLVAVT KIRLARHQRQ QSLADLKQTV AKMPRNHKPD FLIRLKQPGL HVIAEVKKAS
     PSKGTIVTDF PYLAIAKAYD QAGADAISVL TEPDYFNGHL HYLKEISQQV SVPTLRKDFT
     IDPYMIYEAK ANGAVIILLI VAILTDQQLR DYRQLAEKLG MHAIVEAYTA AEVTRALQSG
     AKIIGINNRN LKDFRVDFTN SLKLRAMVPD NIPVVAESGI KTQEDVEKLA AAGFNAILIG
     ETLMRSNQKK QLIAAFKERA