ID   TRPC_LACLA              Reviewed;         264 AA.
AC   Q01999;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=LL1467; ORFNames=L0051;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=1400208; DOI=10.1128/jb.174.20.6563-6570.1992;
RA   Bardowski J., Ehrlich S.D., Chopin A.;
RT   "Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis.";
RL   J. Bacteriol. 174:6563-6570(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; M87483; AAA25226.1; -; Genomic_DNA.
DR   EMBL; AE005176; AAK05565.1; -; Genomic_DNA.
DR   PIR; S35127; S35127.
DR   RefSeq; NP_267623.1; NC_002662.1.
DR   RefSeq; WP_010905988.1; NC_002662.1.
DR   AlphaFoldDB; Q01999; -.
DR   SMR; Q01999; -.
DR   STRING; 272623.L0051; -.
DR   PaxDb; Q01999; -.
DR   EnsemblBacteria; AAK05565; AAK05565; L0051.
DR   KEGG; lla:L0051; -.
DR   PATRIC; fig|272623.7.peg.1577; -.
DR   eggNOG; COG0134; Bacteria.
DR   HOGENOM; CLU_034247_2_1_9; -.
DR   OMA; RGPHDLI; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..264
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154225"
SQ   SEQUENCE   264 AA;  29732 MW;  E7096EE9FA662535 CRC64;
     MNIKKGKFLE TILAEKRLEI AKMPEEQVGK VRQTYNFYDY LKEHSDQLQV IAEVKKASPS
     LGDINLEVDI VDQAKNYEQA GAAMISVLTD PVFFKGNIEY LCEISENVQI PTLNKDFIID
     KKQINRAVNA GATVILLIVA VFENQYPKLQ NLYNYALSLG LEVLVETHNK AELEIAHQLG
     AKIIGVNNRN LKTFEVILQN SVDLTPYFKE DSIYISESGI FSANEAQKVS DTFNGILVGT
     ALMQSENLEK SLKDLKVKRK TNEN