ID   TRPC_METTM              Reviewed;         274 AA.
AC   P26939; D9PUE7;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=MTBMA_c02360;
OS   Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM
OS   14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium
OS   thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=79929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=1860817; DOI=10.1128/jb.173.16.5017-5023.1991;
RA   Meile L., Stettler R., Banholzer R., Kotik M., Leisinger T.;
RT   "Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg:
RT   molecular cloning and nucleotide sequence of a putative trpEGCFBAD
RT   operon.";
RL   J. Bacteriol. 173:5017-5023(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=20802048; DOI=10.1128/jb.00844-10;
RA   Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H.,
RA   Gottschalk G., Thauer R.K.;
RT   "Complete genome sequence of Methanothermobacter marburgensis, a
RT   methanoarchaeon model organism.";
RL   J. Bacteriol. 192:5850-5851(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; M65060; AAA73030.1; -; Genomic_DNA.
DR   EMBL; CP001710; ADL57845.1; -; Genomic_DNA.
DR   RefSeq; WP_013295072.1; NC_014408.1.
DR   AlphaFoldDB; P26939; -.
DR   SMR; P26939; -.
DR   STRING; 79929.MTBMA_c02360; -.
DR   EnsemblBacteria; ADL57845; ADL57845; MTBMA_c02360.
DR   GeneID; 9703942; -.
DR   KEGG; mmg:MTBMA_c02360; -.
DR   PATRIC; fig|79929.8.peg.232; -.
DR   HOGENOM; CLU_034247_0_1_2; -.
DR   OMA; RGPHDLI; -.
DR   OrthoDB; 98284at2157; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000000345; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_A; IGPS_A; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Tryptophan biosynthesis.
FT   CHAIN           1..274
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154295"
SQ   SEQUENCE   274 AA;  30404 MW;  97DBEA8F6445BDAD CRC64;
     MSILQEIIRS RKLEIKNLSR KKPLEELRDE LTSLDEPLSF TDALTGNRVS LICEYKRASP
     SSGRTYGRGL HEMMEVYREG ADAVSVITEN RYFHGSIEFL REASEYGIPL LMKDFVVDEY
     QIYQARASGA SSVLIITGVF PDLESGIETC RELSMEPLVE CHSAIDIYRA IEAGAELIGV
     NNRNLETLEV DLERTRALAP LVPDELLLVS ESGVMGPEDA EILAGCGADA LLIGTSLMLA
     SDPRELLDEI MAAVKSCKPG RKRYSGDEFF EQFA