TRPC_MICAN
ID TRPC_MICAN Reviewed; 296 AA.
AC B0JTM2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134}; OrderedLocusNames=MAE_45030;
OS Microcystis aeruginosa (strain NIES-843 / IAM M-2473).
OC Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC Microcystaceae; Microcystis.
OX NCBI_TaxID=449447;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-843 / IAM M-247;
RX PubMed=18192279; DOI=10.1093/dnares/dsm026;
RA Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M.,
RA Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A.,
RA Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M.,
RA Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.;
RT "Complete genomic structure of the bloom-forming toxic cyanobacterium
RT Microcystis aeruginosa NIES-843.";
RL DNA Res. 14:247-256(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00134};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
CC -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP009552; BAG04325.1; -; Genomic_DNA.
DR RefSeq; WP_004162667.1; NC_010296.1.
DR AlphaFoldDB; B0JTM2; -.
DR SMR; B0JTM2; -.
DR STRING; 449447.MAE_45030; -.
DR PaxDb; B0JTM2; -.
DR EnsemblBacteria; BAG04325; BAG04325; MAE_45030.
DR KEGG; mar:MAE_45030; -.
DR eggNOG; COG0134; Bacteria.
DR HOGENOM; CLU_034247_2_0_3; -.
DR OMA; RGPHDLI; -.
DR OrthoDB; 1789381at2; -.
DR BioCyc; MAER449447:MAE_RS19515-MON; -.
DR UniPathway; UPA00035; UER00043.
DR Proteomes; UP000001510; Chromosome.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00134_B; IGPS_B; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854; PTHR22854; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR PROSITE; PS00614; IGPS; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW Lyase; Reference proteome; Tryptophan biosynthesis.
FT CHAIN 1..296
FT /note="Indole-3-glycerol phosphate synthase"
FT /id="PRO_1000076420"
SQ SEQUENCE 296 AA; 32652 MW; 7187EB3DEADD1E65 CRC64;
MQIRRKHPNP AVKVESLSYV VKVPEAQPQN ILEEIVWHKE IEVDKLRERL PLLELRQKIA
NTAPPCDFLA ALKQGKTQPA LIAEVKKASP SKGVILEDFD PVAIARTYEQ GGATCLSVLT
DSKFFQGSYE NLTLVRQAVS LPLLCKEFIL YPYQIYYARS KGADAVLLIA AILSDQDLAY
FVKIVKGLGM TALVEVHSLA EFDRVLAIEG IELIGINNRN LETFTVDLDN TRQLLEARGE
QVREKGILIV SESGLHTATD LAKVKQAGAN AVLIGESLVK LPDPALGIQK LFENLG
