ID   C135A_MYCTU             Reviewed;         449 AA.
AC   P9WPN1; L0T6C2; O08447;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Putative cytochrome P450 135A1;
DE            EC=1.14.-.-;
GN   Name=cyp135A1; OrderedLocusNames=Rv0327c; ORFNames=MTCY63.32c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43057.1; -; Genomic_DNA.
DR   PIR; H70526; H70526.
DR   RefSeq; NP_214841.1; NC_000962.3.
DR   RefSeq; WP_003401650.1; NZ_NVQJ01000026.1.
DR   AlphaFoldDB; P9WPN1; -.
DR   SMR; P9WPN1; -.
DR   STRING; 83332.Rv0327c; -.
DR   PaxDb; P9WPN1; -.
DR   DNASU; 886538; -.
DR   GeneID; 45424294; -.
DR   GeneID; 886538; -.
DR   KEGG; mtu:Rv0327c; -.
DR   TubercuList; Rv0327c; -.
DR   eggNOG; COG2124; Bacteria.
DR   OMA; GDEHRQM; -.
DR   PhylomeDB; P9WPN1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..449
FT                   /note="Putative cytochrome P450 135A1"
FT                   /id="PRO_0000052292"
FT   BINDING         383
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   449 AA;  50011 MW;  192E3CF1855EDCF5 CRC64;
     MASTLTTGLP PGPRLPRYLQ SVLYLRFREW FLPAMHRKYG DVFSLRVPPY ADNLVVYTRP
     EHIKEIFAAD PRSLHAGEGN HILGFVMGEH SVLMTDEAEH ARMRSLLMPA FTRAALRGYR
     DMIASVAREH ITRWRPHATI NSLDHMNALT LDIILRVVFG VTDPKVKAEL TSRLQQIINI
     HPAILAGVPY PSLKRMNPWK RFFHNQTKID EILYREIASR RIDSDLTART DVLSRLLQTK
     DTPTKPLTDA ELRDQLITLL LAGHETTAAA LSWTLWELAH APEIQSQVVW AAVGGDDGFL
     EAVLKEGMRR HTVIASTARK VTAPAEIGGW RLPAGTVVNT SILLAHASEV SHPKPTEFRP
     SRFLDGSVAP NTWLPFGGGV RRCLGFGFAL TEGAVILQEI FRRFTITAAG PSKGETPLVR
     NITTVPKHGA HLRLIPQRRL GGLGDSDPP