TRPC_PSEA7
ID TRPC_PSEA7 Reviewed; 278 AA.
AC A6UZF2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134}; OrderedLocusNames=PSPA7_0792;
OS Pseudomonas aeruginosa (strain PA7).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=381754;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PA7;
RA Dodson R.J., Harkins D., Paulsen I.T.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00134};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
CC -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
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DR EMBL; CP000744; ABR81206.1; -; Genomic_DNA.
DR RefSeq; WP_012074211.1; NC_009656.1.
DR AlphaFoldDB; A6UZF2; -.
DR SMR; A6UZF2; -.
DR EnsemblBacteria; ABR81206; ABR81206; PSPA7_0792.
DR KEGG; pap:PSPA7_0792; -.
DR HOGENOM; CLU_034247_2_0_6; -.
DR OMA; RGPHDLI; -.
DR OrthoDB; 1789381at2; -.
DR UniPathway; UPA00035; UER00043.
DR Proteomes; UP000001582; Chromosome.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00134_B; IGPS_B; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854; PTHR22854; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR PROSITE; PS00614; IGPS; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW Lyase; Tryptophan biosynthesis.
FT CHAIN 1..278
FT /note="Indole-3-glycerol phosphate synthase"
FT /id="PRO_1000018530"
SQ SEQUENCE 278 AA; 30349 MW; 284636478FB301F4 CRC64;
MSVPTVLQKI LARKAEEVAE RRARVNLAEV ERLARSADAP RGFANALLER ARRKEPAVIA
EIKKASPSKG VLREHFVPAE IARSYEAGGA ACLSVLTDVD FFQGADAYLK EARAACALPV
IRKDFMIDPY QIVEARAIGA DCILLIVSAL DDMLMGELAA TAKSVGLDVL VEVHDGAELE
RALKTLDTPL VGINNRNLHT FEVSLETTLD LLPEIPRDRL VVTESGILNR ADVELMEVSE
VYAFLVGEAF MRADDPGLEL KRLFFQERGG VVLGADPD