TRPC_PSEAE
ID TRPC_PSEAE Reviewed; 278 AA.
AC P20577;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Indole-3-glycerol phosphate synthase;
DE Short=IGPS;
DE EC=4.1.1.48;
GN Name=trpC; OrderedLocusNames=PA0651;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2105306; DOI=10.1128/jb.172.2.853-866.1990;
RA Essar D.W., Eberly L., Han C.Y., Crawford I.P.;
RT "DNA sequences and characterization of four early genes of the tryptophan
RT pathway in Pseudomonas aeruginosa.";
RL J. Bacteriol. 172:853-866(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 258-278.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=8002577; DOI=10.1128/jb.176.24.7532-7542.1994;
RA West S.E.H., Sample A.K., Runyen-Janecky L.J.;
RT "The vfr gene product, required for Pseudomonas aeruginosa exotoxin A and
RT protease production, belongs to the cyclic AMP receptor protein family.";
RL J. Bacteriol. 176:7532-7542(1994).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5.
CC -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR EMBL; M33814; AAA25825.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG04040.1; -; Genomic_DNA.
DR PIR; C35114; C35114.
DR RefSeq; NP_249342.1; NC_002516.2.
DR RefSeq; WP_003113174.1; NZ_QZGE01000010.1.
DR AlphaFoldDB; P20577; -.
DR SMR; P20577; -.
DR STRING; 287.DR97_3604; -.
DR PaxDb; P20577; -.
DR PRIDE; P20577; -.
DR EnsemblBacteria; AAG04040; AAG04040; PA0651.
DR GeneID; 882120; -.
DR KEGG; pae:PA0651; -.
DR PATRIC; fig|208964.12.peg.682; -.
DR PseudoCAP; PA0651; -.
DR HOGENOM; CLU_034247_2_0_6; -.
DR InParanoid; P20577; -.
DR OMA; RGPHDLI; -.
DR PhylomeDB; P20577; -.
DR BioCyc; PAER208964:G1FZ6-656-MON; -.
DR SABIO-RK; P20577; -.
DR UniPathway; UPA00035; UER00043.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IDA:PseudoCAP.
DR GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IBA:GO_Central.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IMP:PseudoCAP.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00134_B; IGPS_B; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854; PTHR22854; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR PROSITE; PS00614; IGPS; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW Lyase; Reference proteome; Tryptophan biosynthesis.
FT CHAIN 1..278
FT /note="Indole-3-glycerol phosphate synthase"
FT /id="PRO_0000154238"
SQ SEQUENCE 278 AA; 30347 MW; 478FEF45378B55F8 CRC64;
MSVPTVLQKI LARKAEEVAE RRARVNLAEV ERLARSADAP RGFANALLER AKRKEPAVIA
EIKKASPSKG VLREHFVPAE IARSYEAGGA ACLSVLTDVD FFQGADAYLK EARAACALPV
IRKDFMIDPY QIVEARAIGA DCILLIVSAL DDVLMAELAA TAKSVGLDVL VEVHDGTELE
RALKTLDTPL VGINNRNLHT FEVSLETTLD LLPEIPRDRL VVTESGILNR ADVELMEVSE
VYAFLVGEAF MRADDPGLEL KRLFFQERGA VVLGADPD
