TRPC_PSEMY
ID TRPC_PSEMY Reviewed; 279 AA.
AC A4XZC5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134}; OrderedLocusNames=Pmen_3944;
OS Pseudomonas mendocina (strain ymp).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=399739;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ymp;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Kiss H., Brettin T., Detter J.C., Bruce D., Han C.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA Hersman L., Dubois J., Maurice P., Richardson P.;
RT "Complete sequence of Pseudomonas mendocina ymp.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00134};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
CC -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
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DR EMBL; CP000680; ABP86691.1; -; Genomic_DNA.
DR RefSeq; WP_004373484.1; NC_009439.1.
DR AlphaFoldDB; A4XZC5; -.
DR SMR; A4XZC5; -.
DR STRING; 399739.Pmen_3944; -.
DR EnsemblBacteria; ABP86691; ABP86691; Pmen_3944.
DR KEGG; pmy:Pmen_3944; -.
DR PATRIC; fig|399739.8.peg.3997; -.
DR eggNOG; COG0134; Bacteria.
DR HOGENOM; CLU_034247_2_0_6; -.
DR OMA; RGPHDLI; -.
DR OrthoDB; 1789381at2; -.
DR UniPathway; UPA00035; UER00043.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00134_B; IGPS_B; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854; PTHR22854; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR PROSITE; PS00614; IGPS; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW Lyase; Tryptophan biosynthesis.
FT CHAIN 1..279
FT /note="Indole-3-glycerol phosphate synthase"
FT /id="PRO_1000018534"
SQ SEQUENCE 279 AA; 30440 MW; 7D454665206BE9A2 CRC64;
MSVPTVLEKI VARKFEEVAA RRVQVSLAEL EAAARAADAP RGFARALLEQ AARKQPAVIA
EIKKASPSKG VLRADFVPAD IARSYEAGGA TCLSVLTDID FFQGADEYLQ QARAACALPV
IRKDFMVDPY QIVEARALGA DCVLLIVSCL DDVRMAELAA VAKDVGLDVL VEVHDGNELE
RALNTLDTPL VGINNRNLHT FEVSLETTLD LLPRIPRERL VVTESGILNR ADVELMEISE
VYAFLVGEAF MRAESPGAEL QRLFFPERGR PTVVGKDPE