ID   TRPC_PSEPU              Reviewed;         277 AA.
AC   P20578;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 23287 / C1S;
RX   PubMed=2404959; DOI=10.1128/jb.172.2.867-883.1990;
RA   Essar D.W., Eberly L., Crawford I.P.;
RT   "Evolutionary differences in chromosomal locations of four early genes of
RT   the tryptophan pathway in fluorescent pseudomonads: DNA sequences and
RT   characterization of Pseudomonas putida trpE and trpGDC.";
RL   J. Bacteriol. 172:867-883(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; M33799; AAA80555.1; -; Genomic_DNA.
DR   PIR; D35115; D35115.
DR   RefSeq; WP_016715789.1; NZ_LKKT01000093.1.
DR   AlphaFoldDB; P20578; -.
DR   SMR; P20578; -.
DR   GeneID; 66678448; -.
DR   UniPathway; UPA00035; UER00043.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Tryptophan biosynthesis.
FT   CHAIN           1..277
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154239"
SQ   SEQUENCE   277 AA;  30550 MW;  6B21E2670F66D8C4 CRC64;
     MSVPTVLERI IARKFQEVAE RSARVSLAEL ERLAKTADAP RGFANALIEQ AKRKQPAVIA
     EIKKASPSKG VIREHFVPAE IAVSYEKGGA TCLSVLTDVD YFQGADEYLQ QARAAVSLPV
     IRKDFMVDPY QIVEARALGA DCVLLIVSAL DDVKMAELAA TAKDVGLDVL VEVHDGDELE
     RALKTLDTPL VGVNNRNLHT FEVSLETTLD LLPRIPRDRL AITESGILNR ADVELMAINE
     VYSFLVGEAF MRAEQPGLEL QRLFFPEQVK KTVQPLD