TRPC_PYRAB
ID TRPC_PYRAB Reviewed; 229 AA.
AC Q9V1G3; G8ZGG8;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134}; OrderedLocusNames=PYRAB04640;
GN ORFNames=PAB2043;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00134};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
CC -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
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DR EMBL; AJ248284; CAB49386.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE69847.1; -; Genomic_DNA.
DR PIR; C75163; C75163.
DR RefSeq; WP_010867588.1; NC_000868.1.
DR AlphaFoldDB; Q9V1G3; -.
DR SMR; Q9V1G3; -.
DR STRING; 272844.PAB2043; -.
DR EnsemblBacteria; CAB49386; CAB49386; PAB2043.
DR GeneID; 1495360; -.
DR KEGG; pab:PAB2043; -.
DR PATRIC; fig|272844.11.peg.491; -.
DR eggNOG; arCOG01088; Archaea.
DR HOGENOM; CLU_034247_0_1_2; -.
DR OMA; RGPHDLI; -.
DR OrthoDB; 98284at2157; -.
DR PhylomeDB; Q9V1G3; -.
DR UniPathway; UPA00035; UER00043.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00134_A; IGPS_A; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854; PTHR22854; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR PROSITE; PS00614; IGPS; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW Lyase; Tryptophan biosynthesis.
FT CHAIN 1..229
FT /note="Indole-3-glycerol phosphate synthase"
FT /id="PRO_0000154297"
SQ SEQUENCE 229 AA; 25737 MW; 061890FECF394417 CRC64;
MVIFGLSRRI KRCTKNPIIA ELKVYSPKYG DLLRGRDPLE ILRRYERAGA VGISYITDPK
YFRGNFDFFK RLCKETELPV LRKDFITTKE EIEKTAEAGG SAVLLITRLL KDKLPEFVDH
AREHGLDTLV EVHTLEELKI AIQTNSTMIG INNRDIGKLE LDDGNVSLTA KLAPLIPDKF
VKVSESGITT LEDLKVALKY ADAALIGTAL MKTEDPEKLL KSFVEAKIC
