ID   TRPC_PYRFU              Reviewed;         228 AA.
AC   Q8U088;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE            Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE            EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN   Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134}; OrderedLocusNames=PF1711;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00134};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
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DR   EMBL; AE009950; AAL81835.1; -; Genomic_DNA.
DR   RefSeq; WP_011012857.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8U088; -.
DR   SMR; Q8U088; -.
DR   STRING; 186497.PF1711; -.
DR   EnsemblBacteria; AAL81835; AAL81835; PF1711.
DR   GeneID; 41713542; -.
DR   KEGG; pfu:PF1711; -.
DR   PATRIC; fig|186497.12.peg.1779; -.
DR   eggNOG; arCOG01088; Archaea.
DR   HOGENOM; CLU_034247_0_1_2; -.
DR   OMA; RGPHDLI; -.
DR   OrthoDB; 98284at2157; -.
DR   PhylomeDB; Q8U088; -.
DR   SABIO-RK; Q8U088; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_A; IGPS_A; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..228
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154299"
SQ   SEQUENCE   228 AA;  25308 MW;  04D1ADCAF187ADA9 CRC64;
     MVIFGLSRAI RKAKKNPIIA EIKVYSPKYG DLLRGRDPLR ILRAYEEAGA VGISYITDQK
     YFKGSFDFLK VLCKETTLPV LRKDFITSKE EIEKTAEVGA SAVLLITRIL KDKLPEFVDY
     AKEHGLDTLV EVHTEDELKL AIKTNSTMIG INNRDIGKLE MDDGDVSLTE ILAPKIPGKF
     VKVSESGIAT LEDLKRALRV ADAALIGTAL MKAENPAELL KKFVEAEI