ID   TRPC_RHOCB              Reviewed;         264 AA.
AC   Q02584; D5ALM8;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=RCAP_rcc02359;
OS   Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Rhodobacter.
OX   NCBI_TaxID=272942;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003;
RX   PubMed=1644778; DOI=10.1128/jb.174.16.5482-5484.1992;
RA   Becker-Rudzik M.A., Young D.A., Marrs B.L.;
RT   "Sequence of the indoleglycerol phosphate synthase (trpC) gene from
RT   Rhodobacter capsulatus.";
RL   J. Bacteriol. 174:5482-5484(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003;
RX   PubMed=20418398; DOI=10.1128/jb.00366-10;
RA   Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V.,
RA   Haselkorn R.;
RT   "Complete genome sequence of the photosynthetic purple nonsulfur bacterium
RT   Rhodobacter capsulatus SB 1003.";
RL   J. Bacteriol. 192:3545-3546(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; M97640; AAA26181.1; -; Genomic_DNA.
DR   EMBL; CP001312; ADE86089.1; -; Genomic_DNA.
DR   PIR; A42948; A42948.
DR   RefSeq; WP_013068068.1; NC_014034.1.
DR   AlphaFoldDB; Q02584; -.
DR   SMR; Q02584; -.
DR   STRING; 272942.RCAP_rcc02359; -.
DR   EnsemblBacteria; ADE86089; ADE86089; RCAP_rcc02359.
DR   GeneID; 31491192; -.
DR   KEGG; rcp:RCAP_rcc02359; -.
DR   eggNOG; COG0134; Bacteria.
DR   HOGENOM; CLU_034247_2_0_5; -.
DR   OMA; RGPHDLI; -.
DR   OrthoDB; 1789381at2; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000002361; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..264
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154247"
FT   CONFLICT        42..43
FT                   /note="AE -> GQ (in Ref. 1; AAA26181)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        77..78
FT                   /note="AL -> V (in Ref. 1; AAA26181)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        109..119
FT                   /note="ARNACALPALR -> RGTPAPCPPS (in Ref. 1; AAA26181)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        207..208
FT                   /note="QL -> HV (in Ref. 1; AAA26181)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        228..229
FT                   /note="PA -> R (in Ref. 1; AAA26181)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   264 AA;  28266 MW;  2DDEF476A161E04B CRC64;
     MTNILDRIKA YKLEEVAAAK ARVSFADLEA QARAQAPCRG FAEALRKKSA QGYGLIAEIK
     KASPSKGLIR PDFDPPALAR AYEDGGAACL SVLTDTPSFQ GAPDYLIAAR NACALPALRK
     DFLYDPYQVA EARAWGADCI LIIMASVEDA LAVELEAAAT GWGMDVLIEV HDGAELDRAL
     KWLKSPLLGV NNRNLKTFEV TLDVTRQLAP VILAEGRELV CESGIFTPAD MAAMAAVGAR
     RFLIGESLMR QADVAAATRA LLAC