ID   C13AA_BACTU             Reviewed;         803 AA.
AC   Q45755;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Pesticidal crystal protein Cry13Aa;
DE   AltName: Full=88 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryXIIIA(a);
GN   Name=cry13Aa; Synonyms=cryVC, cryXIIIA(a);
OS   Bacillus thuringiensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1428;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL B-18246 / PS63B;
RA   Schnepf H.E., Schwab G.E., Payne J.M., Narva K.E., Foncerrada L.;
RT   "Novel nematode-active toxins and genes which code therefor.";
RL   Patent number WO9219739, 09-DEC-1992.
CC   -!- FUNCTION: Endotoxin with nematicidal activity.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; L07023; AAA22356.1; -; Genomic_DNA.
DR   RefSeq; WP_065482087.1; NZ_CP015350.1.
DR   AlphaFoldDB; Q45755; -.
DR   SMR; Q45755; -.
DR   TCDB; 1.C.2.3.1; the channel-forming Delta-endotoxin insecticidal crystal protein (icp) family.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..803
FT                   /note="Pesticidal crystal protein Cry13Aa"
FT                   /id="PRO_0000174086"
SQ   SEQUENCE   803 AA;  88143 MW;  680E57C6A246A826 CRC64;
     MTCQLQAQPL IPYNVLAGVP TSNTGSPIGN AGNQFDQFEQ TVKELKEAWE AFQKNGSFSL
     AALEKGFDAA IGGGSFDYLG LVQAGLGLVG TLGAAIPGVS VAVPLISMLV GVFWPKGTNN
     QENLITVIDK EVQRILDEKL SDQLIKKLNA DLNAFTDLVT RLEEVIIDAT FENHKPVLQV
     SKSNYMKVDS AYFSTGGILT LGMSDFLTDT YSKLTFPLYV LGATMKLSAY HSYIQFGNTW
     LNKVYDLSSD EGKTMSQALA RAKQHMRQDI AFYTSQALNM FTGNLPSLSS NKYAINDYNV
     YTRAMVLNGL DIVATWPTLY PDDYSSQIKL EKTRVIFSDM VGQSESRDGS VTIKNIFDNT
     DSHQHGSIGL NSISYFPDEL QKAQLRMYDY NHKPYCTDCF CWPYGVILNY NKNTFRYGDN
     DPGLSGDVQL PAPMSVVNAQ TQTAQYTDGE NIWTDTGRSW LCTLRGYCTT NCFPGRGCYN
     NSTGYGESCN QSLPGQKIHA LYPFTQTNVL GQSGKLGLLA SHIPYDLSPN NTIGDKDTDS
     TNIVAKGIPV EKGYASSGQK VEIIREWING ANVVQLSPGQ SWGMDFTNST GGQYMVRCRY
     ASTNDTPIFF NLVYDGGSNP IYNQMTFPAT KETPAHDSVD NKILGIKGIN GNYSLMNVKD
     SVELPSGKFH VFFTNNGSSA IYLDRLEFVP LDQPAAPTQS TQPINYPITS RLPHRSGEPP
     AIIWEKSGNV RGNQLTISAQ GVPENSQIYL SVGGDRQILD RSNGFKLVNY SPTYSFTNIQ
     ASSSNLVDIT SGTITGQVQV SNL