TRPC_SYNPW
ID TRPC_SYNPW Reviewed; 294 AA.
AC A5GMK4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134};
GN OrderedLocusNames=SynWH7803_1743;
OS Synechococcus sp. (strain WH7803).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC unclassified Synechococcus.
OX NCBI_TaxID=32051;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH7803;
RG Genoscope;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00134};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
CC -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC Rule:MF_00134}.
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DR EMBL; CT971583; CAK24169.1; -; Genomic_DNA.
DR RefSeq; WP_011933641.1; NC_009481.1.
DR AlphaFoldDB; A5GMK4; -.
DR SMR; A5GMK4; -.
DR STRING; 32051.SynWH7803_1743; -.
DR EnsemblBacteria; CAK24169; CAK24169; SynWH7803_1743.
DR KEGG; syx:SynWH7803_1743; -.
DR eggNOG; COG0134; Bacteria.
DR HOGENOM; CLU_034247_2_0_3; -.
DR OMA; RGPHDLI; -.
DR OrthoDB; 1789381at2; -.
DR UniPathway; UPA00035; UER00043.
DR Proteomes; UP000001566; Chromosome.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00331; IGPS; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00134_B; IGPS_B; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854; PTHR22854; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR PROSITE; PS00614; IGPS; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW Lyase; Reference proteome; Tryptophan biosynthesis.
FT CHAIN 1..294
FT /note="Indole-3-glycerol phosphate synthase"
FT /id="PRO_1000018558"
SQ SEQUENCE 294 AA; 31988 MW; ACAD105B750ACAD7 CRC64;
MEIRRRPPNP KVQVAHLEYA IPHQDGEPRN ILEKIVWEKD REIETARQRM PLVQLKARVA
ELPPALDFLG ALRQAPVAPA VIAEVKKASP SKGVIREDFD PVAIAKAYAA GGASCLSVLT
DRTFFQGGFD VLVAVREAVD LPLLCKDFIL SPHQLYQARA AGADAALLIA AILTDQDLAY
LQKVAATLGL TVLVEVHDAA EMERILTLGG FPLIGINNRD LTSFETDLAT TEALTQQFAD
RLRAQDAFLV SESGLFARAD LNRVQRSGAG AVLVGEALMR QDNVEQGLRD LIAP
