ID   TRPC_THEAC              Reviewed;         237 AA.
AC   Q9HK02;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=Ta0808;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; AL445065; CAC11937.1; -; Genomic_DNA.
DR   RefSeq; WP_010901220.1; NC_002578.1.
DR   AlphaFoldDB; Q9HK02; -.
DR   SMR; Q9HK02; -.
DR   STRING; 273075.Ta0808; -.
DR   EnsemblBacteria; CAC11937; CAC11937; CAC11937.
DR   GeneID; 1456353; -.
DR   KEGG; tac:Ta0808; -.
DR   eggNOG; arCOG01088; Archaea.
DR   HOGENOM; CLU_034247_0_1_2; -.
DR   OMA; CEYRRER; -.
DR   OrthoDB; 98284at2157; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_A; IGPS_A; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..237
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154304"
SQ   SEQUENCE   237 AA;  26939 MW;  8E9F9548B5811C1D CRC64;
     MNIEDIFANN RTRSCEYRRE RRTVSLRRAI ELCNGEGRRG LIAEYKRRSP SGFSTDEDIS
     SYLSYVKMHR IAGLSILSEP THFSGSFDDV TLAHRIGVPV LVKDFAPDDH FVESAYNAGG
     DAVLAILDFL PSEDVERIVR RSADLGMDVI EEYHDRKALK KFVDGDNVIL GYNRRDLVSL
     KTGEDQDMPQ YDITILESGI NIDNVVHVDM RYSGFLIGTS ILKRDGTLEY LEKNRII