ID   TRPC_THEKO              Reviewed;         227 AA.
AC   Q9YGB5; Q5JFU4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=TK0252;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=10628865; DOI=10.1007/s004380051145;
RA   Tang X., Ezaki S., Fujiwara S., Takagi M., Atomi H., Imanaka T.;
RT   "The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus
RT   kodakaraensis KOD1 is regulated at the transcriptional level and expressed
RT   as a single mRNA.";
RL   Mol. Gen. Genet. 262:815-821(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000305}.
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DR   EMBL; AB030011; BAA82545.1; -; Genomic_DNA.
DR   EMBL; AP006878; BAD84441.1; -; Genomic_DNA.
DR   PIR; T43922; T43922.
DR   AlphaFoldDB; Q9YGB5; -.
DR   SMR; Q9YGB5; -.
DR   STRING; 69014.TK0252; -.
DR   PRIDE; Q9YGB5; -.
DR   EnsemblBacteria; BAD84441; BAD84441; TK0252.
DR   KEGG; tko:TK0252; -.
DR   PATRIC; fig|69014.16.peg.251; -.
DR   eggNOG; arCOG01088; Archaea.
DR   HOGENOM; CLU_034247_0_1_2; -.
DR   InParanoid; Q9YGB5; -.
DR   OMA; RGPHDLI; -.
DR   PhylomeDB; Q9YGB5; -.
DR   BioCyc; MetaCyc:MON-3581; -.
DR   BRENDA; 4.1.1.48; 5246.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IBA:GO_Central.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IBA:GO_Central.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IBA:GO_Central.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_A; IGPS_A; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854; PTHR22854; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..227
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154300"
FT   CONFLICT        215
FT                   /note="P -> R (in Ref. 1; BAA82545)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   227 AA;  25374 MW;  A91D797C71B162D4 CRC64;
     MVFGLSRAIR KAEKNAIIAE LKVYSPKYGD LLKGRNPFEI LRAYERAGAV GISYITDPKY
     FRGSFEFLRK LCRETELPVL RKDFIASKEE VERTAEAGAS AVLLITRLLK EELPEFVDFA
     KEHGLDTLVE VHSEEELAIA LQTDSTMIGI NNRDIGKLEL DDGNVSLTEK LAPLIPKRYV
     KVSESGIAGT EDLKRALRHA DAALIGTALM KTPDPEEFLR KLVEVEV