C144B_HUMAN
ID C144B_HUMAN Reviewed; 725 AA.
AC Q3MJ40; Q6P5Q3; Q8N200;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Coiled-coil domain-containing protein 144B;
GN Name=CCDC144B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3MJ40-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3MJ40-2; Sequence=VSP_029792, VSP_029793;
CC -!- SIMILARITY: Belongs to the CCDC144 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH62767.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK093811; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; EF553518; ABQ66264.1; -; mRNA.
DR EMBL; AC026271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC062767; AAH62767.1; ALT_SEQ; mRNA.
DR EMBL; BC101585; AAI01586.1; -; mRNA.
DR EMBL; BC104815; AAI04816.1; -; mRNA.
DR AlphaFoldDB; Q3MJ40; -.
DR SMR; Q3MJ40; -.
DR DIP; DIP-47329N; -.
DR IntAct; Q3MJ40; 5.
DR MINT; Q3MJ40; -.
DR iPTMnet; Q3MJ40; -.
DR PhosphoSitePlus; Q3MJ40; -.
DR BioMuta; HGNC:26704; -.
DR DMDM; 121942840; -.
DR MassIVE; Q3MJ40; -.
DR PeptideAtlas; Q3MJ40; -.
DR PRIDE; Q3MJ40; -.
DR GeneCards; CCDC144B; -.
DR HGNC; HGNC:26704; CCDC144B.
DR neXtProt; NX_Q3MJ40; -.
DR PharmGKB; PA162381474; -.
DR InParanoid; Q3MJ40; -.
DR PhylomeDB; Q3MJ40; -.
DR PathwayCommons; Q3MJ40; -.
DR ChiTaRS; CCDC144B; human.
DR Pharos; Q3MJ40; Tdark.
DR PRO; PR:Q3MJ40; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q3MJ40; protein.
DR InterPro; IPR040118; C144A/B/C.
DR PANTHER; PTHR22245; PTHR22245; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..725
FT /note="Coiled-coil domain-containing protein 144B"
FT /id="PRO_0000312280"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 215..244
FT /evidence="ECO:0000255"
FT COILED 490..546
FT /evidence="ECO:0000255"
FT COILED 648..713
FT /evidence="ECO:0000255"
FT COMPBIAS 103..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 222
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029792"
FT VAR_SEQ 573..725
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029793"
FT CONFLICT 370
FT /note="K -> N (in Ref. 1; AK093811)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 725 AA; 82951 MW; 7F77DCDCA99E87C6 CRC64;
MASWGGEKRG GAEGSPKLAV YATRKTRSVR SQEDQWYLGY PGDQWSSGFS YSWWKNSVGS
ESKHGEGALD QPQHDVRLED LGELHRAARS GDVPGVEHVL APGDTGVDKR DRKKSIQQLV
PEYKEKQTPE SLPQNNNPDW HPTNLTLSDE TCQRSKNLKV GDKSPSVSPS MPENQSATKE
LGQMNLTERE KMDTGVVLLS GNDTLHDLCQ SQLPENKESK EAEQDLELTS EEEQERLKGC
ENKQPQKTSQ EPEMAKDCDR EDIPIYPVLP HVQKSEEMWI EQGKLEWKNQ LKLVINELKQ
RFGEIYEKYK IPACPEEEPL LDNSTRGTDV KDIPFNLTNN IPGCEEEDAS EISVSVVFET
FPEQKEPSLK NIIHPYYHPY SGSQEHVCQS SSKLHLHENK LDCDNDNKLG IGHIFSTDNN
FHNDASTKKA RNPEVVTVEM KEDQEFDLQM TKNMNQNSDS GSTNNYKSLK PKLENLSSLP
PDSDRTSEVY LHEELQQDMQ KFKNEVNTLE EEFLALKKEN VQLHKEVEEE MEKHRSNSTE
LSGTLTDGTT VGNDDDGLNQ QIPRKENEEH DRPADKTANE KNKVKNQIYP EADFADSMEP
SEIASEDCEL SHSVYENFML LIEQLRMEYK DSASLPRIQD TFCLCEHLLK LKNNHCDQLT
VKLKQMENMV SVLQNELSET KKTKLQLELQ KIEWEKELYD LRLALKQENG RKEMPICCII
KIVNS
