C163B_HUMAN
ID C163B_HUMAN Reviewed; 1453 AA.
AC Q9NR16; B4E0G7; C9JHR7; E7EVK4; Q2M3B7; Q6UWC2;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Scavenger receptor cysteine-rich type 1 protein M160;
DE AltName: Full=CD163 antigen-like 1;
DE AltName: CD_antigen=CD163b;
DE Flags: Precursor;
GN Name=CD163L1; Synonyms=CD163B, M160; ORFNames=UNQ6434/PRO23202;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP VARIANT MET-523.
RX PubMed=11086079; DOI=10.4049/jimmunol.165.11.6406;
RA Groenlund J., Vitved L., Lausen M., Skjoedt K., Holmskov U.;
RT "Cloning of a novel scavenger receptor cysteine-rich type I transmembrane
RT molecule (M160) expressed by human macrophages.";
RL J. Immunol. 165:6406-6415(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT MET-523.
RX PubMed=20032174; DOI=10.1128/jvi.02093-09;
RA Van Gorp H., Van Breedam W., Van Doorsselaere J., Delputte P.L.,
RA Nauwynck H.J.;
RT "Identification of the CD163 protein domains involved in infection of the
RT porcine reproductive and respiratory syndrome virus.";
RL J. Virol. 84:3101-3105(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT MET-523.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT MET-523.
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT MET-523.
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 41-55.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [8]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1161.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of multiple
RT enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-
CC pass type I membrane protein {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-
CC pass type I membrane protein {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=M160-alpha;
CC IsoId=Q9NR16-1; Sequence=Displayed;
CC Name=2; Synonyms=M160-beta;
CC IsoId=Q9NR16-2; Sequence=VSP_016877;
CC Name=3;
CC IsoId=Q9NR16-3; Sequence=VSP_016875, VSP_016876;
CC Name=4;
CC IsoId=Q9NR16-4; Sequence=VSP_047557;
CC -!- TISSUE SPECIFICITY: Isoform 1 is highly expressed in the spleen, lymph
CC nodes, thymus, and fetal liver and weakly expressed in bone marrow and
CC no expression was found in peripheral blood leukocytes. Isoform 1
CC expression is restricted to the monocyte and macrophage cell lines.
CC Isoform 2 is only expressed in spleen. {ECO:0000269|PubMed:11086079}.
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DR EMBL; AF264014; AAF91396.1; -; mRNA.
DR EMBL; GQ397482; ADB45259.1; -; mRNA.
DR EMBL; AY358856; AAQ89215.1; -; mRNA.
DR EMBL; AK303372; BAG64429.1; -; mRNA.
DR EMBL; AC131205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104962; AAI04963.1; -; mRNA.
DR EMBL; BC104964; AAI04965.1; -; mRNA.
DR CCDS; CCDS73434.1; -. [Q9NR16-4]
DR CCDS; CCDS8577.1; -. [Q9NR16-1]
DR RefSeq; NP_001284579.1; NM_001297650.1. [Q9NR16-4]
DR RefSeq; NP_777601.2; NM_174941.5. [Q9NR16-1]
DR RefSeq; XP_011518918.1; XM_011520616.1. [Q9NR16-2]
DR PDB; 6K0O; X-ray; 1.99 A; A/B=795-895.
DR PDBsum; 6K0O; -.
DR AlphaFoldDB; Q9NR16; -.
DR SMR; Q9NR16; -.
DR STRING; 9606.ENSP00000393474; -.
DR GlyGen; Q9NR16; 17 sites.
DR iPTMnet; Q9NR16; -.
DR PhosphoSitePlus; Q9NR16; -.
DR BioMuta; CD163L1; -.
DR DMDM; 296434413; -.
DR jPOST; Q9NR16; -.
DR MassIVE; Q9NR16; -.
DR PaxDb; Q9NR16; -.
DR PeptideAtlas; Q9NR16; -.
DR PRIDE; Q9NR16; -.
DR ProteomicsDB; 18658; -.
DR ProteomicsDB; 82250; -. [Q9NR16-1]
DR ProteomicsDB; 82251; -. [Q9NR16-2]
DR ProteomicsDB; 82252; -. [Q9NR16-3]
DR Antibodypedia; 3051; 124 antibodies from 21 providers.
DR DNASU; 283316; -.
DR Ensembl; ENST00000313599.8; ENSP00000315945.3; ENSG00000177675.9. [Q9NR16-1]
DR Ensembl; ENST00000416109.2; ENSP00000393474.2; ENSG00000177675.9. [Q9NR16-4]
DR GeneID; 283316; -.
DR KEGG; hsa:283316; -.
DR MANE-Select; ENST00000313599.8; ENSP00000315945.3; NM_174941.6; NP_777601.3.
DR UCSC; uc001qsy.4; human. [Q9NR16-1]
DR CTD; 283316; -.
DR DisGeNET; 283316; -.
DR GeneCards; CD163L1; -.
DR HGNC; HGNC:30375; CD163L1.
DR HPA; ENSG00000177675; Tissue enhanced (intestine, lymphoid tissue).
DR MIM; 606079; gene.
DR neXtProt; NX_Q9NR16; -.
DR OpenTargets; ENSG00000177675; -.
DR PharmGKB; PA142672145; -.
DR VEuPathDB; HostDB:ENSG00000177675; -.
DR eggNOG; ENOG502QQ5W; Eukaryota.
DR GeneTree; ENSGT00940000164229; -.
DR HOGENOM; CLU_002555_0_0_1; -.
DR InParanoid; Q9NR16; -.
DR OMA; GVNCYGK; -.
DR OrthoDB; 1095487at2759; -.
DR PhylomeDB; Q9NR16; -.
DR TreeFam; TF329295; -.
DR PathwayCommons; Q9NR16; -.
DR BioGRID-ORCS; 283316; 13 hits in 1066 CRISPR screens.
DR ChiTaRS; CD163L1; human.
DR GenomeRNAi; 283316; -.
DR Pharos; Q9NR16; Tbio.
DR PRO; PR:Q9NR16; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NR16; protein.
DR Bgee; ENSG00000177675; Expressed in rectum and 108 other tissues.
DR ExpressionAtlas; Q9NR16; baseline and differential.
DR Genevisible; Q9NR16; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR Gene3D; 3.10.250.10; -; 12.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR Pfam; PF00530; SRCR; 12.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 12.
DR SUPFAM; SSF56487; SSF56487; 12.
DR PROSITE; PS00420; SRCR_1; 5.
DR PROSITE; PS50287; SRCR_2; 12.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell membrane;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Secreted; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..40
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 41..1453
FT /note="Scavenger receptor cysteine-rich type 1 protein
FT M160"
FT /id="PRO_0000045392"
FT TOPO_DOM 41..1359
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1360..1380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1381..1453
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 48..148
FT /note="SRCR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 155..255
FT /note="SRCR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 262..362
FT /note="SRCR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 369..469
FT /note="SRCR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 476..576
FT /note="SRCR 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 583..683
FT /note="SRCR 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 690..790
FT /note="SRCR 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 795..895
FT /note="SRCR 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 900..1000
FT /note="SRCR 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 1036..1136
FT /note="SRCR 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 1141..1243
FT /note="SRCR 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 1246..1346
FT /note="SRCR 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT REGION 1418..1453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1418..1434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 334
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 377
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 441
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 548
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 637
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 972
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1013
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1084
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT CARBOHYD 1171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1318
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1354
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 73..137
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 86..147
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 117..127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 180..244
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 193..254
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 224..234
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 287..351
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 300..361
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 331..341
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 394..458
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 407..468
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 438..448
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 501..565
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 514..575
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 545..555
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 608..672
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 621..682
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 652..662
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 715..779
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 728..789
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 759..769
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 820..884
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 833..894
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 864..874
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 925..989
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 938..999
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 969..979
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1061..1125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1074..1135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1105..1115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1181..1242
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1212..1222
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1271..1335
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1284..1345
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 1315..1325
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT VAR_SEQ 148
FT /note="Y -> YGKSLTRVGRQ (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047557"
FT VAR_SEQ 718..727
FT /note="GWGMNIAEVV -> SFLMTSSKPR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_016875"
FT VAR_SEQ 728..1453
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_016876"
FT VAR_SEQ 1395..1426
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11086079"
FT /id="VSP_016877"
FT VARIANT 523
FT /note="L -> M (in dbSNP:rs6488268)"
FT /evidence="ECO:0000269|PubMed:11086079,
FT ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:20032174"
FT /id="VAR_059810"
FT VARIANT 578
FT /note="D -> N (in dbSNP:rs4072797)"
FT /id="VAR_057206"
FT VARIANT 582
FT /note="G -> A (in dbSNP:rs4072796)"
FT /id="VAR_057207"
FT VARIANT 1055
FT /note="G -> S (in dbSNP:rs36206713)"
FT /id="VAR_057208"
FT VARIANT 1108
FT /note="M -> T (in dbSNP:rs35480970)"
FT /id="VAR_057209"
FT CONFLICT 105
FT /note="T -> S (in Ref. 4; BAG64429)"
FT /evidence="ECO:0000305"
FT CONFLICT 333
FT /note="G -> V (in Ref. 4; BAG64429)"
FT /evidence="ECO:0000305"
FT CONFLICT 1234
FT /note="P -> T (in Ref. 1; AAF91396 and 3; AAQ89215)"
FT /evidence="ECO:0000305"
FT CONFLICT 1359
FT /note="H -> R (in Ref. 1; AAF91396 and 3; AAQ89215)"
FT /evidence="ECO:0000305"
FT CONFLICT 1373
FT /note="L -> P (in Ref. 1; AAF91396 and 3; AAQ89215)"
FT /evidence="ECO:0000305"
FT STRAND 795..799
FT /evidence="ECO:0007829|PDB:6K0O"
FT STRAND 805..812
FT /evidence="ECO:0007829|PDB:6K0O"
FT STRAND 815..818
FT /evidence="ECO:0007829|PDB:6K0O"
FT HELIX 826..835
FT /evidence="ECO:0007829|PDB:6K0O"
FT STRAND 840..845
FT /evidence="ECO:0007829|PDB:6K0O"
FT TURN 847..850
FT /evidence="ECO:0007829|PDB:6K0O"
FT STRAND 855..857
FT /evidence="ECO:0007829|PDB:6K0O"
FT STRAND 859..862
FT /evidence="ECO:0007829|PDB:6K0O"
FT HELIX 871..873
FT /evidence="ECO:0007829|PDB:6K0O"
FT STRAND 876..878
FT /evidence="ECO:0007829|PDB:6K0O"
FT HELIX 886..888
FT /evidence="ECO:0007829|PDB:6K0O"
FT STRAND 891..894
FT /evidence="ECO:0007829|PDB:6K0O"
SQ SEQUENCE 1453 AA; 159239 MW; EBF90FBEE4FDF4CE CRC64;
MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL VNGDGPCSGT
VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF GQAVTRHGKI WLDDVSCYGN
ESALWECQHR EWGSHNCYHG EDVGVNCYGE ANLGLRLVDG NNSCSGRVEV KFQERWGTIC
DDGWNLNTAA VVCRQLGCPS SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG
NHDCSHNEDV TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC
KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD CLHQNDVSVI
CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN EQALVVCKQL GCPFSVFGSR
RAKPSNEARD IWINSISCTG NESALWDCTY DGKAKRTCFR RSDAGVICSD KADLDLRLVG
AHSPCYGRLE VKYQGEWGTV CHDRWSTRNA AVVCKQLGCG KPLHVFGMTY FKEASGPIWL
DDVSCIGNES NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF
QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV SCDGDESDLW
SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA GKVEVNVQGA VGILCANGWG
MNIAEVVCRQ LECGSAIRVS REPHFTERTL HILMSNSGCT GGEASLWDCI RWEWKQTACH
LNMEASLICS AHRQPRLVGA DMPCSGRVEV KHADTWRSVC DSDFSLHAAN VLCRELNCGD
AISLSVGDHF GKGNGLTWAE KFQCEGSETH LALCPIVQHP EDTCIHSREV GVVCSRYTDV
RLVNGKSQCD GQVEINVLGH WGSLCDTHWD PEDARVLCRQ LSCGTALSTT GGKYIGERSV
RVWGHRFHCL GNESLLDNCQ MTVLGAPPCI HGNTVSVICT GSLTQPLFPC LANVSDPYLS
AVPEGSALIC LEDKRLRLVD GDSRCAGRVE IYHDGFWGTI CDDGWDLSDA HVVCQKLGCG
VAFNATVSAH FGEGSGPIWL DDLNCTGMES HLWQCPSRGW GQHDCRHKED AGVICSEFTA
LRLYSETETE SCAGRLEVFY NGTWGSVGRR NITTAIAGIV CRQLGCGENG VVSLAPLSKT
GSGFMWVDDI QCPKTHISIW QCLSAPWERR ISSPAEETWI TCEDRIRVRG GDTECSGRVE
IWHAGSWGTV CDDSWDLAEA EVVCQQLGCG SALAALRDAS FGQGTGTIWL DDMRCKGNES
FLWDCHAKPW GQSDCGHKED AGVRCSGQSL KSLNASSGHL ALILSSIFGL LLLVLFILFL
TWCRVQKQKH LPLRVSTRRR GSLEENLFHE METCLKREDP HGTRTSDDTP NHGCEDASDT
SLLGVLPASE ATK
