C16L2_HUMAN
ID C16L2_HUMAN Reviewed; 174 AA.
AC Q6UWJ8; B2RPJ0; Q5JXD6;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 3.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=CD164 sialomucin-like 2 protein;
DE Flags: Precursor;
GN Name=CD164L2; ORFNames=UNQ6122/PRO20044;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT MET-76.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-76.
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-76.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT MET-76.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 30-44.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- INTERACTION:
CC Q6UWJ8-2; Q8N682: DRAM1; NbExp=3; IntAct=EBI-13362802, EBI-10305400;
CC Q6UWJ8-2; Q9Y342: PLLP; NbExp=3; IntAct=EBI-13362802, EBI-3919291;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UWJ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWJ8-2; Sequence=VSP_017031;
CC -!- SIMILARITY: Belongs to the CD164 family. {ECO:0000305}.
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DR EMBL; AY358761; AAQ89121.1; -; mRNA.
DR EMBL; AL096774; CAI19568.1; -; Genomic_DNA.
DR EMBL; AL096774; CAI19569.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07755.1; -; Genomic_DNA.
DR EMBL; BC137466; AAI37467.1; -; mRNA.
DR CCDS; CCDS302.1; -. [Q6UWJ8-2]
DR CCDS; CCDS81287.1; -. [Q6UWJ8-1]
DR RefSeq; NP_001317377.1; NM_001330448.1. [Q6UWJ8-1]
DR RefSeq; NP_997280.2; NM_207397.4. [Q6UWJ8-2]
DR RefSeq; XP_011539743.1; XM_011541441.1. [Q6UWJ8-2]
DR AlphaFoldDB; Q6UWJ8; -.
DR BioGRID; 132771; 36.
DR IntAct; Q6UWJ8; 7.
DR STRING; 9606.ENSP00000363139; -.
DR GlyGen; Q6UWJ8; 2 sites.
DR iPTMnet; Q6UWJ8; -.
DR PhosphoSitePlus; Q6UWJ8; -.
DR BioMuta; CD164L2; -.
DR DMDM; 85700457; -.
DR PaxDb; Q6UWJ8; -.
DR PeptideAtlas; Q6UWJ8; -.
DR PRIDE; Q6UWJ8; -.
DR ProteomicsDB; 67487; -. [Q6UWJ8-1]
DR ProteomicsDB; 67488; -. [Q6UWJ8-2]
DR Antibodypedia; 74085; 12 antibodies from 9 providers.
DR DNASU; 388611; -.
DR Ensembl; ENST00000374027.7; ENSP00000363139.3; ENSG00000174950.11. [Q6UWJ8-2]
DR Ensembl; ENST00000374030.3; ENSP00000363142.1; ENSG00000174950.11. [Q6UWJ8-1]
DR GeneID; 388611; -.
DR KEGG; hsa:388611; -.
DR MANE-Select; ENST00000374030.3; ENSP00000363142.1; NM_001330448.1; NP_001317377.1.
DR UCSC; uc031tuv.2; human. [Q6UWJ8-1]
DR CTD; 388611; -.
DR DisGeNET; 388611; -.
DR GeneCards; CD164L2; -.
DR HGNC; HGNC:32043; CD164L2.
DR HPA; ENSG00000174950; Tissue enhanced (esophagus, fallopian tube, salivary gland).
DR neXtProt; NX_Q6UWJ8; -.
DR OpenTargets; ENSG00000174950; -.
DR PharmGKB; PA142672146; -.
DR VEuPathDB; HostDB:ENSG00000174950; -.
DR eggNOG; ENOG502S6M0; Eukaryota.
DR GeneTree; ENSGT00530000063929; -.
DR HOGENOM; CLU_133331_0_0_1; -.
DR InParanoid; Q6UWJ8; -.
DR OMA; AVQGGCK; -.
DR OrthoDB; 1643926at2759; -.
DR PhylomeDB; Q6UWJ8; -.
DR TreeFam; TF333380; -.
DR PathwayCommons; Q6UWJ8; -.
DR SignaLink; Q6UWJ8; -.
DR BioGRID-ORCS; 388611; 11 hits in 1068 CRISPR screens.
DR GenomeRNAi; 388611; -.
DR Pharos; Q6UWJ8; Tdark.
DR PRO; PR:Q6UWJ8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6UWJ8; protein.
DR Bgee; ENSG00000174950; Expressed in right uterine tube and 77 other tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007947; CD164_MGC24.
DR PANTHER; PTHR11337; PTHR11337; 1.
DR Pfam; PF05283; MGC-24; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 30..174
FT /note="CD164 sialomucin-like 2 protein"
FT /id="PRO_0000045779"
FT TOPO_DOM 30..141
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..174
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 174
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_017031"
FT VARIANT 76
FT /note="V -> M (in dbSNP:rs2504779)"
FT /id="VAR_057508"
FT CONFLICT 68
FT /note="G -> R (in Ref. 1; AAQ89121, 4; AAI37467, 2;
FT CAI19568/CAI19569 and 3; EAX07755)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 174 AA; 18403 MW; 530099138820ADFB CRC64;
MEAPGPRALR TALCGGCCCL LLCAQLAVAG KGARGFGRGA LIRLNIWPAV QGACKQLEVC
EHCVEGDGAR NLSSCVWEQC RPEEPGHCVA QSEVVKEGCS IYNRSEACPA AHHHPTYEPK
TVTTGSPPVP EAHSPGFDGA SFIGGVVLVL SLQAVAFFVL HFLKAKDSTY QTLI
