C16L2_MOUSE
ID C16L2_MOUSE Reviewed; 172 AA.
AC Q9D6W7; B1AUM9;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=CD164 sialomucin-like 2 protein;
DE Flags: Precursor;
GN Name=Cd164l2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CD164 family. {ECO:0000305}.
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DR EMBL; AK009888; BAB26564.1; -; mRNA.
DR EMBL; AL671858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38901.1; -.
DR RefSeq; NP_081428.1; NM_027152.1.
DR AlphaFoldDB; Q9D6W7; -.
DR STRING; 10090.ENSMUSP00000101530; -.
DR GlyGen; Q9D6W7; 2 sites.
DR iPTMnet; Q9D6W7; -.
DR PhosphoSitePlus; Q9D6W7; -.
DR PaxDb; Q9D6W7; -.
DR PRIDE; Q9D6W7; -.
DR ProteomicsDB; 265323; -.
DR Antibodypedia; 74085; 12 antibodies from 9 providers.
DR Ensembl; ENSMUST00000105910; ENSMUSP00000101530; ENSMUSG00000028865.
DR GeneID; 69655; -.
DR KEGG; mmu:69655; -.
DR UCSC; uc008vcj.1; mouse.
DR CTD; 388611; -.
DR MGI; MGI:1916905; Cd164l2.
DR VEuPathDB; HostDB:ENSMUSG00000028865; -.
DR eggNOG; ENOG502S6M0; Eukaryota.
DR GeneTree; ENSGT00530000063929; -.
DR HOGENOM; CLU_133331_0_0_1; -.
DR InParanoid; Q9D6W7; -.
DR OMA; AVQGGCK; -.
DR OrthoDB; 1643926at2759; -.
DR PhylomeDB; Q9D6W7; -.
DR TreeFam; TF333380; -.
DR BioGRID-ORCS; 69655; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q9D6W7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D6W7; protein.
DR Bgee; ENSMUSG00000028865; Expressed in secondary oocyte and 84 other tissues.
DR Genevisible; Q9D6W7; MM.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007947; CD164_MGC24.
DR PANTHER; PTHR11337; PTHR11337; 1.
DR Pfam; PF05283; MGC-24; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000250"
FT CHAIN 30..172
FT /note="CD164 sialomucin-like 2 protein"
FT /id="PRO_0000045780"
FT TOPO_DOM 30..137
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 108..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 172 AA; 18220 MW; CF3682E28447E5B9 CRC64;
MAAPGPRALR AALCGGCCCL LLCAQLVLAG KGARGFGRGA LLRLNVWPTT QGGCKHLGHC
EHCVDRAHNF SICVWQQCGP EEPGHCVAQA EVVKEGCSIY NHSESCPASH HHSTEEPKPS
TTGSPPIPED HSPGFDGASF IGGIVLVLSL QATAFFVLRF LKAKDSTYQT LI
