C170B_HUMAN
ID C170B_HUMAN Reviewed; 1589 AA.
AC Q9Y4F5; Q2KHR7; Q86TI7;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 4.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Centrosomal protein of 170 kDa protein B;
DE AltName: Full=Centrosomal protein 170B;
DE Short=Cep170B;
GN Name=CEP170B; Synonyms=FAM68C, KIAA0284;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=9179496; DOI=10.1093/dnares/4.1.53;
RA Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N.,
RA Nomura N.;
RT "Construction and characterization of human brain cDNA libraries suitable
RT for analysis of cDNA clones encoding relatively large proteins.";
RL DNA Res. 4:53-59(1997).
RN [2]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R., Nomura N.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1404-1589 (ISOFORMS 1/2/3).
RC TISSUE=Eye, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-597; SER-655; SER-721;
RP SER-746; SER-748; SER-751; SER-753; SER-986; SER-988; SER-1135; THR-1304
RP AND SER-1545, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-986; SER-988; SER-1135 AND
RP THR-1304, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1545 AND SER-1548, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-986 AND SER-988, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360; SER-421; SER-492;
RP SER-597; SER-721; SER-772; SER-829; SER-853; SER-972; SER-1135 AND
RP SER-1179, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-542; SER-619; SER-655;
RP SER-829; SER-853; SER-954 AND SER-1548, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Plays a role in microtubule organization.
CC {ECO:0000250|UniProtKB:Q5SW79}.
CC -!- INTERACTION:
CC Q9Y4F5-3; P22607: FGFR3; NbExp=3; IntAct=EBI-12950757, EBI-348399;
CC Q9Y4F5-3; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-12950757, EBI-10226858;
CC Q9Y4F5-3; P01112: HRAS; NbExp=3; IntAct=EBI-12950757, EBI-350145;
CC Q9Y4F5-3; P54652: HSPA2; NbExp=3; IntAct=EBI-12950757, EBI-356991;
CC Q9Y4F5-3; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12950757, EBI-741158;
CC Q9Y4F5-3; P49591: SARS1; NbExp=3; IntAct=EBI-12950757, EBI-1053431;
CC Q9Y4F5-3; Q15645: TRIP13; NbExp=3; IntAct=EBI-12950757, EBI-358993;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q498L0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9Y4F5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y4F5-2; Sequence=VSP_024248;
CC Name=3;
CC IsoId=Q9Y4F5-3; Sequence=VSP_024247;
CC -!- SIMILARITY: Belongs to the CEP170 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH47913.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAA22953.3; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB006622; BAA22953.3; ALT_INIT; mRNA.
DR EMBL; AL583810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047913; AAH47913.1; ALT_FRAME; mRNA.
DR EMBL; BC112928; AAI12929.1; -; mRNA.
DR CCDS; CCDS45175.1; -. [Q9Y4F5-2]
DR CCDS; CCDS45176.2; -. [Q9Y4F5-3]
DR PIR; T00037; T00037.
DR RefSeq; NP_001106197.1; NM_001112726.2. [Q9Y4F5-2]
DR RefSeq; NP_055820.2; NM_015005.2. [Q9Y4F5-3]
DR RefSeq; XP_005267607.1; XM_005267550.3. [Q9Y4F5-1]
DR RefSeq; XP_011534967.1; XM_011536665.2. [Q9Y4F5-1]
DR RefSeq; XP_011534968.1; XM_011536666.2. [Q9Y4F5-1]
DR AlphaFoldDB; Q9Y4F5; -.
DR SMR; Q9Y4F5; -.
DR BioGRID; 129628; 59.
DR IntAct; Q9Y4F5; 29.
DR STRING; 9606.ENSP00000404151; -.
DR GlyGen; Q9Y4F5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9Y4F5; -.
DR PhosphoSitePlus; Q9Y4F5; -.
DR BioMuta; CEP170B; -.
DR DMDM; 143342098; -.
DR EPD; Q9Y4F5; -.
DR jPOST; Q9Y4F5; -.
DR MassIVE; Q9Y4F5; -.
DR MaxQB; Q9Y4F5; -.
DR PaxDb; Q9Y4F5; -.
DR PeptideAtlas; Q9Y4F5; -.
DR PRIDE; Q9Y4F5; -.
DR ProteomicsDB; 86197; -. [Q9Y4F5-1]
DR ProteomicsDB; 86198; -. [Q9Y4F5-2]
DR ProteomicsDB; 86199; -. [Q9Y4F5-3]
DR Antibodypedia; 54848; 41 antibodies from 13 providers.
DR DNASU; 283638; -.
DR Ensembl; ENST00000414716.8; ENSP00000404151.2; ENSG00000099814.17. [Q9Y4F5-2]
DR Ensembl; ENST00000556508.5; ENSP00000451249.1; ENSG00000099814.17. [Q9Y4F5-3]
DR GeneID; 283638; -.
DR KEGG; hsa:283638; -.
DR MANE-Select; ENST00000414716.8; ENSP00000404151.2; NM_001112726.3; NP_001106197.1. [Q9Y4F5-2]
DR UCSC; uc001yps.4; human. [Q9Y4F5-1]
DR CTD; 283638; -.
DR DisGeNET; 283638; -.
DR GeneCards; CEP170B; -.
DR HGNC; HGNC:20362; CEP170B.
DR HPA; ENSG00000099814; Low tissue specificity.
DR neXtProt; NX_Q9Y4F5; -.
DR OpenTargets; ENSG00000099814; -.
DR PharmGKB; PA134863153; -.
DR VEuPathDB; HostDB:ENSG00000099814; -.
DR eggNOG; ENOG502QSH8; Eukaryota.
DR GeneTree; ENSGT00940000157058; -.
DR InParanoid; Q9Y4F5; -.
DR OrthoDB; 83451at2759; -.
DR PhylomeDB; Q9Y4F5; -.
DR TreeFam; TF328469; -.
DR PathwayCommons; Q9Y4F5; -.
DR SignaLink; Q9Y4F5; -.
DR BioGRID-ORCS; 283638; 20 hits in 1074 CRISPR screens.
DR ChiTaRS; CEP170B; human.
DR GenomeRNAi; 283638; -.
DR Pharos; Q9Y4F5; Tdark.
DR PRO; PR:Q9Y4F5; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9Y4F5; protein.
DR Bgee; ENSG00000099814; Expressed in pancreatic ductal cell and 194 other tissues.
DR ExpressionAtlas; Q9Y4F5; baseline and differential.
DR Genevisible; Q9Y4F5; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR029300; CEP170_C.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR Pfam; PF15308; CEP170_C; 1.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1589
FT /note="Centrosomal protein of 170 kDa protein B"
FT /id="PRO_0000282889"
FT DOMAIN 23..73
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 130..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1350..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1532..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..550
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1126..1140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 360
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 421
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 480
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U49"
FT MOD_RES 492
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 536
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U49"
FT MOD_RES 542
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 597
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 619
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 655
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 711
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U49"
FT MOD_RES 721
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 746
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 748
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 751
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 753
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 772
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 829
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 853
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 954
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 972
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 986
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692"
FT MOD_RES 988
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692"
FT MOD_RES 1135
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163"
FT MOD_RES 1179
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1199
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U49"
FT MOD_RES 1304
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332"
FT MOD_RES 1356
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U49"
FT MOD_RES 1362
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80U49"
FT MOD_RES 1545
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231"
FT MOD_RES 1548
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:24275569"
FT VAR_SEQ 1..70
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024247"
FT VAR_SEQ 1247..1282
FT /note="NTRRRQQGSDYTSTSEEEYGSRHGSPKHTRSHTSTA -> T (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:9179496"
FT /id="VSP_024248"
FT CONFLICT 315
FT /note="A -> T (in Ref. 1; BAA22953)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1589 AA; 171688 MW; B232960C12A81244 CRC64;
MSATSWFLVS SSGARHRLPR ELIFVGREEC ELMLQSRSVD KQHAVINYDQ DRDEHWVKDL
GSLNGTFVND MRIPDQKYVT LKLNDVIRFG YDSNMYVLER VQHRVPEEAL KHEKYTSQLQ
VSVKGLAPKR SEALPEHTPY CEASNPRPEK GDRRPGTEAA SYRTPLYGQP SWWGEDDGST
LPDAQRQGEP YPERPKGPVQ QDGELHGFRA PAEPQGCSFR REPSYFEIPT KETPQPSQPP
EVPAHEMPTK DAEAGGGGAA PVVQSHASFT IEFDDCSPGK MKIKDHITKF SLRQRRPPGK
EATPGEMVSA ETKVADWLVQ NDPSLLHRVG PGDDRHSTKS DLPVHTRTLK GHKHEDGTQS
DSEDPLAKAA SAAGVPLEAS GEQVRLQRQI KRDPQELLHN QQAFVIEFFD EDTPRKKRSQ
SFTHSPSGDP KADKRRGPTP ADRDRPSVPA PVQAGGRSSG PQRAGSLKRE KTEERLGSPS
PASRTPARPF GSVGRRSRLA QDFMAQCLRE SSPAARPSPE KVPPVLPAPL TPHGTSPVGP
PTPPPAPTDP QLTKARKQEE DDSLSDAGTY TIETEAQDTE VEEARKMIDQ VFGVLESPEL
SRASSATFRP VIRGDRDESD DGGVAQRMAL LQEFASRPLG AAPQAEHQGL PVPGSPGGQK
WVSRWASLAD SYSDPGLTED GLGRRGGEPE GSLPVRMRRR LPQLPSERAD SPAGPESSRR
SGPGPPELDS EQPSRLFGQE ELDPDSLSDA SGSDGGRGPE PGVEPQDSRR RSPQEGPTWS
RGRRSPRAPG EPTPASFFIG DQNGDAVLSR KPLAAPGDGE GLGQTAQPSP PARDGVYVSA
NGRMVIQLRP GRSPEPDGPA PAFLRQESFT KEPASGPPAP GKPPHISSHP LLQDLAATRA
ARMDFHSQDT HLILKETETA LAALEARLLS NSVDAECEGG STPRPPEDAL SGDSDVDTAS
TVSLRSGKSG PSPTTPQPLR AQKEMSPSPP AAQDPGGTAL VSAREQSSER QHHPLGPTDM
GRGEPVRRSA IRRGHRPRGS LDWPSEERGP VLAHLPSSDV MASNHETPEA TGAGRLGSRR
KPAAPPPSPA AREEQSRSSA SSQKGPQALT RSNSLSTPRP TRASRLRRAR LGDASDTEAA
DGERGSLGNP EPVGRPAAEQ AKKLSRLDIL AMPRKRAGSF TGTSDPEAAP ARTSFSGRSV
ELCCASRKPT MAEARAVSRK AANTATTTGP RQPFSRARSG SARYTSNTRR RQQGSDYTST
SEEEYGSRHG SPKHTRSHTS TATQTPRAGS SSRARSRAPG PRDTDDDEEE PDPYGFIVQT
AEIAEIARLS QTLVKDVAIL AQEIHDVAGD GDTLGSSEPA HSASLSNMPS TPASTISARE
ELVQRIPEAS LNFQKVPPGS LNSRDFDQNM NDSCEDALAN KTRPRNREEV IFDNLMLNPV
SQLSQAIREN TEHLAEKMKI LFQNTGRAWE DLEARINAEN EVPILKTSNK EISSILKELR
RVQKQLEVIN AIVDPSGSLD LLTGNRSLAS SAQPGLGKGR VAAQSPPSPA SAEALLPALP
LRNFPQRASC GPPSLPDPTF LPDAERFLI
