C170B_XENLA
ID C170B_XENLA Reviewed; 1610 AA.
AC Q498L0;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Centrosomal protein of 170 kDa protein B;
DE AltName: Full=Centrosomal protein 170B;
DE Short=Cep170B;
GN Name=cep170b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in microtubule organization.
CC {ECO:0000250|UniProtKB:Q5SW79}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CEP170 family. {ECO:0000305}.
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DR EMBL; BC100173; AAI00174.1; -; mRNA.
DR RefSeq; NP_001089648.1; NM_001096179.1.
DR AlphaFoldDB; Q498L0; -.
DR SMR; Q498L0; -.
DR BioGRID; 592489; 1.
DR IntAct; Q498L0; 1.
DR PRIDE; Q498L0; -.
DR GeneID; 734708; -.
DR KEGG; xla:734708; -.
DR CTD; 734708; -.
DR Xenbase; XB-GENE-5943463; cep170b.S.
DR OrthoDB; 83451at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 734708; Expressed in zone of skin and 16 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR029300; CEP170_C.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR Pfam; PF15308; CEP170_C; 2.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT CHAIN 1..1610
FT /note="Centrosomal protein of 170 kDa protein B"
FT /id="PRO_0000282891"
FT DOMAIN 23..73
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 148..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1253..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1361..1404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1540..1610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1126..1140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1363..1391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1610 AA; 179342 MW; 38F454C97D092DE0 CRC64;
MSVTSWFLVS SSGTRHRLPR EMIFVGREDC ELMLRSRSVD KQHAVINYDS DKDEHRVKDL
GSLNGTFIND VRIPDQKYIT LKLNDNIRFG YDINTYVLEQ IQHQVPEEAL KYCDPPVIAF
EQIPASSDKH EKYTSHLQMC SKTSAVREDQ FKEQGAHMDS SQAKQEKVDK KSATDVPAYR
TPLYGQPSWW GEDDDNKLGK EGRSQDEHYS ERPKDMTQHE EEVSDNMGYR DSPDQCMYPF
RREPSYFEIP TKDFQQPVKP PETQVYEIPT KDTDTVPPVT PPVMQSHASF TIEFDDCKPG
KIKIKDHVTK PSMRQRKTAG KEPGPTEMVS AESKVADWLV HNDPSLIRRP SPGEDVYSTK
SDLPIHNRTL KGNKHEDGTQ SDSEDPLVTK PEQETGTADH PQHQRQFNRE PEELLHSQQA
FVIEFFDDDA PRKKRSQSFT HNSNSPPNDT DPILKAKVDK RKGTVHVEKV STNGTGSTAP
ASKSLSSPSF PQRSNSFRRE KTEDRIASTP ITARLPGKNY GSVGKKSKLA QEFAAEYMHE
QAEVVKQAAE KPMTLPLSAS ILQQPASQVQ ISSQVQAMPV TSDVRSETIK NEEEDNLSDA
GTYTIETETQ DREVEQARKM IDQVFGVFEP DEYSKISSTV YRPVINKGKE EHLGSEPSMT
HKPIMSLSTP PIKLSNGLQA EPLIERPGSS SKSGQKWVSR WASLADSYPD ASPTSPSDSQ
KQGFIADDED VIERIEVQGE ADPTVPSRTR RLLPQLPPEN VMPTIFVCQE SFSAESQRKH
VEEPEKGISA ENSSLLLVQE ELDPDSLSDT SRSDDGVLSV RKSAKASKIY RNGWKGEEPH
SRESSVQRTL VSSSEKKSTC FYVGNDDMGS LKQTTSGLSS KDVVKNHESH INLKANVHSN
VETPSAERLV NQFHKKENGS AKDPLSFVRQ ESFTKEKSSS NVSPNKLPHI STHPLLKDLS
VTKSSHDYSQ ETRLILKETE TALAALEAKL FTQSHLDELE NTPSLRDDSL SGESDVDTAS
TVSLVSDKNA PIHSQQNRIV NLQKEKSSST SSIQEQYCQS SARERLSEKR RTVPADAGTR
SITKRVGMTR STGARGSLDF TDEERSSSLP YMPVSETVSS DYENSSSRHI SRRKPIGQTC
KEDSSRSSNA QKVQQALTRS NSLSTPRPTR ASKLRRARLG ESSDNECADG ERSNISPGTS
SANSSSAKSS TEPKKPSRLD ILAMPRKRAG SFNVPSDSET YSSVKAMFSG RSVDQTYTSR
KPAVAESKQP PKKPVAPTQK QTPSKARSSS VKYSSSSTTQ TSRSSSVSRH HKSSRQDEDE
VEQEVYNNFM AQSVEIAEIA RLSQTLVKDV ASLAREIHDV AGDGDSQSSS GTGQSTSISS
VPNTPASTIS AREETIKRPL QRTRPLQLVH HIPEASLNYQ KIPPGSTGLE DFDQNMNDSR
EDPSKRRARN IEEVIFDNLM LNPVSQLSHT ICSDTEVLTE KMKVLFQNTE KNWEEIEAKI
NSENEVPILK TSNKEISSIL KELRRVQKQL EVINAIIDRS GNPEDTASNK KTSSTLLTSN
ALPRTTNNSA ARTQSQTPGH LRNYIHKSSS SSSRSPGSSF SRDDEETYIV
