C170B_XENTR
ID C170B_XENTR Reviewed; 1628 AA.
AC A0JM08;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Centrosomal protein of 170 kDa protein B;
DE AltName: Full=Centrosomal protein 170B;
DE Short=Cep170B;
GN Name=cep170b;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in microtubule organization.
CC {ECO:0000250|UniProtKB:Q5SW79}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q498L0}.
CC -!- SIMILARITY: Belongs to the CEP170 family. {ECO:0000305}.
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DR EMBL; BC125690; AAI25691.1; -; mRNA.
DR RefSeq; NP_001072723.1; NM_001079255.1.
DR AlphaFoldDB; A0JM08; -.
DR SMR; A0JM08; -.
DR STRING; 8364.ENSXETP00000053089; -.
DR PaxDb; A0JM08; -.
DR PRIDE; A0JM08; -.
DR GeneID; 780180; -.
DR KEGG; xtr:780180; -.
DR CTD; 283638; -.
DR Xenbase; XB-GENE-5943417; cep170b.
DR eggNOG; ENOG502QSH8; Eukaryota.
DR InParanoid; A0JM08; -.
DR OrthoDB; 83451at2759; -.
DR Proteomes; UP000008143; Chromosome 8.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000002232; Expressed in neurula embryo and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR029300; CEP170_C.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR Pfam; PF15308; CEP170_C; 1.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT CHAIN 1..1628
FT /note="Centrosomal protein of 170 kDa protein B"
FT /id="PRO_0000282892"
FT DOMAIN 23..73
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 136..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1443..1463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1172..1195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1265..1299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1381..1405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1628 AA; 181490 MW; A502B29694E5A961 CRC64;
MSVTSWFLVS SSGTRHRLPR EMIFVGREDC ELMLQSRSVD KQHAVINYDS DKDEHRVKDL
GSLNGTFVND VRIPDQKYIT LKLSDNIRFG YDINTYVLEQ IQHQVPEEAL KHEKYTSHLQ
MCLKTAAAGR EDQFKEHGAH VDSAQAKQDK ADKKATSDIP AYRTPLYGQP SWWGEDDDNK
LDKEGRRQDE HYSERPNDMT QHEEEINGNM SYRDSQDQCV YPFRREPSYF EIPTKDFQQP
VKPPETQVYE IPTKDTDAVP PVTPPVMQSH ASFTIEFDDC QPGKIKIKDH VTKFSMRQRK
TAGKEPAPTE MVSAESKVAD WLVQNDPSLI RRPAPGEDVY STKSDLPIHN RTLKGNRHED
GTQSDSEDPL VAQPEQEIGT PDHPQLQRQI KREPEELLHN QQAFVIQFFD DDDAPRKKRS
QSFTHNANSP QNDTDPVLKA KAEKRKGTLH VEKVSTNGMG STAPASKSLS SPSFPQRSNS
FRREKTEDRI SSAPTTAKLP GKNYGSVGKK SKLAQEFAAE YMREQVEVVK QAAEKPMTLP
LSTSILQQPA SQVQISSQAQ TMQLTSDVRT GKVKNEEEDN LSDAGTYTIE TETQDREVEQ
ARKMIDQVFG VFESDEYSKI ASTVYRPVIK LGEEEPLASE PSVPHKPIMS STPPVKLSNG
LPAETLIERT GSSSKQSQKW VSRWASLADS YPDASPTSPL DSQKQGLIAD DEDVIERTEH
QGEADPTVPS RTRRLLPQLP PENVMPTIFV CQESFSDESQ RKSLEEPEKR ISEENSSLLL
VQEELDPDSL SDTSKSDDGV ISVRKSAKAS NTYRNGWKGE ESHSREPSVQ RTSVPSNEKK
STCFYVGNDD VGSVKQTSFG LSSKDVIKGP ESHIKMKVNL HITAETPSSG KAVNQFPKKD
NGSAKDPLSF VRQESFTKET SSSNVLPNKL PHISTHPLLK DLSVTKSNHD YSKETRLILK
ETETALAALE AKLFTQSHLD EIENTPCLRD DSLSGDSDVD TASTVSLVSD KNVPSHSQKN
RIVSLQKEKS SSTSSIQEQY CQPSARERLS EKRRTVPADA GTRNVTKRLG MTRSTGARGS
LDFTDEERCS SLPYMPVSET VSSDYEHSSS RHISRRKPFG QTCKDESSRS SNAQKVQQAL
TRSNSLSTPR PTRASKLRRA RLGESSDNES ADVERSNISP GTSSANSSSA KSSTETKKPS
RLDILAMPRK RAGSFNVPSD SETTSSVRGM FSGRSIDQSY TSRKPAVAES KQPPKKPLPP
TQKQTPRPRS SSVKYSSSST SRRRQQGSDY VSTSEEECGS NHSTPKHKHS RASTATQTSR
SSSVSRRQMP NSRQDEEEDE QEVYNNFMAQ SVEIAEIARL SQTLVKDVAS LAREIHDVAG
DGDSQSSSGT GQSTSISSVP NTPASTISAR EEIIKRSLQR TCSSQLVHHI PEASLNYQKI
PPGSTGLEDF DQNMNDSRED PSKRRARNIE EVIFDNLMLN PVSHLSHTIC ANTEVLTEKM
KILFQNTEKN WEEIEAKINS ENEVPILKTS NKEISSILKE LRRVQKQLEV INAIIDRSGH
LDVPSSNKKT SSTILTSNPL SRTTNNSAAR TESQTPGHVR NYMHKSSSSS SRSPGSSFSR
DDEETYIV
