ID   C18CA_PAEPP             Reviewed;         695 AA.
AC   P57092;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Parasporal crystal protein Cry18Ca;
DE   AltName: Full=78 kDa crystal protein;
DE   AltName: Full=Crystaline parasporal protoxin;
DE   AltName: Full=Parasporal delta-endotoxin CryXVIIIC(a);
GN   Name=cry18Ca; Synonyms=cryXVIIIC(a);
OS   Paenibacillus popilliae (Bacillus popilliae).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=78057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14706 / DSM 2047 / BCRC 14650 / CIP 106066 / NCCB 75017 / NRRL
RC   B-2309;
RA   Patel R., Yousten A.A., Rippere K.;
RT   "Detection of two new cry genes in Paenibacillus popilliae.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to the brush border membrane vesicles of scarab larvae
CC       and damages the gut wall somehow to allow the vegetative cells of
CC       P.popilliae to enter the hemolymph. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; AF169251; AAF89668.1; -; Genomic_DNA.
DR   AlphaFoldDB; P57092; -.
DR   SMR; P57092; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 2.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR015214; Pest_cryst_cen_dom_Cry2A/18.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF09131; Endotoxin_mid; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..695
FT                   /note="Parasporal crystal protein Cry18Ca"
FT                   /id="PRO_0000174093"
SQ   SEQUENCE   695 AA;  78259 MW;  406AC9154D75E070 CRC64;
     MNNYFIGKVL SGHHINNNGN GNTLSRTALT PTNNNVNRGD LVTNGLTPID NNFIGSNGFI
     PRNVTRKDPF RKRTTQEFIR EWTEWKEKSA SLFTAPIVGV ITSTLLEALK KLVAGRVLMS
     LTNLLFPNNS TSTMEEILRA TEQYIQEQLD TVTWNRVSQE LEGLKNDLRT FNDQIDDFLQ
     NRVGISPLAI IDSINTMQQL FVNRLPQFQV SDDQVLLLPL FAQAVTLHLT FVRDIIINAD
     EWNIPEAQLN TYKRYLKQYV AQYSNYALST YEEAFRARFY PRNTVENMLE FKTFMTLNVL
     DLVSMWSLLK YVNLYVSTSA NLYNIGDNKV NEGEYSISYW PFFNTYIQTK SNYVLSGVSG
     YAMRWSYTNP FFGEYIQDHL YNITASYIGG VNGPQIGQQL STTELDQLVQ QQARADIPVD
     FTQIPINCTL RNPLEVPYYA TRFNELTSLG TAGVGGFVRS DVFISNDSVC GLGTNYSSGQ
     TFYPDYYITN ISATVQVNGT NTDISPLYFG ENRAITSTNG VNKVIAIYNR KTNYDDFTNI
     RGTIVHEAPT DSTGFTISPL HLDTVNINSY LYIQENYGNN GDSLRVINRA IIKYRLSAAR
     SVIYRLVLRV SGTASSIVAI YENYPVGSAN QINTGTDNEG VIDNDSKFID LIFNTPFSVS
     GTARELQLQV SGATTSSPLD IMNIILIPIN DVPLY