ID   C19AA_BACTJ             Reviewed;         648 AA.
AC   O32307;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Pesticidal crystal protein Cry19Aa;
DE   AltName: Full=75 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryXIXA(a);
GN   Name=cry19Aa; Synonyms=cryXIXA(a);
OS   Bacillus thuringiensis subsp. jegathesan.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=56955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=367;
RX   PubMed=9361431; DOI=10.1128/aem.63.11.4449-4455.1997;
RA   Rosso M.-L., Delecluse A.;
RT   "Contribution of the 65-kilodalton protein encoded by the cloned gene
RT   cry19A to the mosquitocidal activity of Bacillus thuringiensis subsp.
RT   jegathesan.";
RL   Appl. Environ. Microbiol. 63:4449-4455(1997).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of mosquitos.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; Y07603; CAA68875.1; -; Genomic_DNA.
DR   AlphaFoldDB; O32307; -.
DR   SMR; O32307; -.
DR   PRIDE; O32307; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..648
FT                   /note="Pesticidal crystal protein Cry19Aa"
FT                   /id="PRO_0000174094"
SQ   SEQUENCE   648 AA;  74743 MW;  E4A8FBA4570DE5B9 CRC64;
     MHYYGNRNEY DILNASSNDS NMSNTYPRYP LANPQQDLMQ NTNYKDWLNV CEGYHIENPR
     EASVRAGLGK GLGIVSTIVG FFGGSIILDT IGLFYQISEL LWPEDDTQQY TWQDIMNHVE
     DLIDKRITEV IRGNAIRTLA DLQGKVDDYN NWLKKWKDDP KSTGNLSTLV TKFTALDSDF
     NGAIRTVNNQ GSPGYELLLL PVYAQIANLH LLLLRDAQIY GDKWWSARAN ARDNYYQIQL
     EKTKEYTEYC INWYNKGLND FRTAGQWVNF NRYRREMTLT VLDIISMFPI YDARLYPTEV
     KTELTREIYS DVINGEIYGL MTPYFSFEKA ESLYTRAPHL FTWLKGFRFV TNSISYWTFL
     SGGQNKYSYT NNSSINEGSF RGQDTDYGGT SSTINIPSNS YVYNLWTENY EYIYPWGDPV
     NITKMNFSVT DNNSSKELIY GAHRTNKPVV RTDFDFLTNK EGTELAKYND YNHILSYMLI
     NGETFGQKRH GYSFAFTHSS VDPNNTIAAN KITQIPVVKA SSINGSISIE KGPGFTGGDL
     VKMRADSGLT MRFKAELLDK KYRVRIRYKC NYSSKLILRK WKGEGYIQQQ IHNISPTYGA
     FSYLESFTIT TTENIFDLTM EVTYPYGRQF VEDIPSLILD KIEFLPTN